| pubmed-article:2840898 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2840898 | lifeskim:mentions | umls-concept:C0205753 | lld:lifeskim |
| pubmed-article:2840898 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:2840898 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2840898 | lifeskim:mentions | umls-concept:C0066808 | lld:lifeskim |
| pubmed-article:2840898 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2840898 | pubmed:dateCreated | 1988-8-29 | lld:pubmed |
| pubmed-article:2840898 | pubmed:abstractText | An investigation on the conformations of highly receptor-selective opioid peptides was carried out to gain further understanding of the structure-activity relationship of endogenous enkephalins. The preferred conformations of a highly mu-selective [Val4]morphiceptin and a highly delta-selective delta-kephalin have been probed by 1H n.m.r. solvent-, concentration- and temperature-dependences of amide protons to take the folded conformations stabilized by an intramolecular hydrogen bond and the anti-parallely extended dimeric structures respectively. Their possible stereo-conformations were proposed, based on the analyses of the vicinal coupling constants (JHNC alpha H). The conformational difference between the mu- and delta-selective opioid peptides was further ascertained by the c.d. measurements. The c.d. spectra of the mu-selective peptides show negative bands in the range of 210-230 nm, while those of the delta-selective ones show the opposite positive bands. A correlation between c.d. spectra and receptor-selectivity was possible. | lld:pubmed |
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| pubmed-article:2840898 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2840898 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2840898 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2840898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2840898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2840898 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2840898 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2840898 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2840898 | pubmed:author | pubmed-author:TanakaMM | lld:pubmed |
| pubmed-article:2840898 | pubmed:author | pubmed-author:InoueMM | lld:pubmed |
| pubmed-article:2840898 | pubmed:author | pubmed-author:IshidaTT | lld:pubmed |
| pubmed-article:2840898 | pubmed:author | pubmed-author:KitamuraKK | lld:pubmed |
| pubmed-article:2840898 | pubmed:author | pubmed-author:DoiMM | lld:pubmed |
| pubmed-article:2840898 | pubmed:author | pubmed-author:IkumaKK | lld:pubmed |
| pubmed-article:2840898 | pubmed:author | pubmed-author:NabaeMM | lld:pubmed |
| pubmed-article:2840898 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2840898 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2840898 | pubmed:volume | 251 | lld:pubmed |
| pubmed-article:2840898 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2840898 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2840898 | pubmed:pagination | 581-8 | lld:pubmed |
| pubmed-article:2840898 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2840898 | pubmed:meshHeading | pubmed-meshheading:2840898-... | lld:pubmed |
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| pubmed-article:2840898 | pubmed:meshHeading | pubmed-meshheading:2840898-... | lld:pubmed |
| pubmed-article:2840898 | pubmed:meshHeading | pubmed-meshheading:2840898-... | lld:pubmed |
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| pubmed-article:2840898 | pubmed:meshHeading | pubmed-meshheading:2840898-... | lld:pubmed |
| pubmed-article:2840898 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2840898 | pubmed:articleTitle | Conformational characteristics of receptor-selective opioid peptides. 1H n.m.r. and c.d. spectroscopic studies of delta-kephalin and [Val4]morphiceptin. | lld:pubmed |
| pubmed-article:2840898 | pubmed:affiliation | Osaka University of Pharmaceutical Sciences, Japan. | lld:pubmed |
| pubmed-article:2840898 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2840898 | lld:pubmed |
