| pubmed-article:2833366 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2833366 | lifeskim:mentions | umls-concept:C0346627 | lld:lifeskim |
| pubmed-article:2833366 | lifeskim:mentions | umls-concept:C0034703 | lld:lifeskim |
| pubmed-article:2833366 | lifeskim:mentions | umls-concept:C0021851 | lld:lifeskim |
| pubmed-article:2833366 | lifeskim:mentions | umls-concept:C0031855 | lld:lifeskim |
| pubmed-article:2833366 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:2833366 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2833366 | pubmed:dateCreated | 1988-5-20 | lld:pubmed |
| pubmed-article:2833366 | pubmed:abstractText | Epidemiological data demonstrate correlations between dietary factors and the incidence of large intestinal cancer (LIC). Certain high-fiber diets are associated with a lower risk of LIC; these high-fiber diets are also rich in inositol hexaphosphate (IP6 or phytic acid). In a pilot study, we have used F344 rats to investigate the effect of sodium inositol hexaphosphate (Na-IP6) prior to (experiment I) and following injections of the carcinogen azoxymethane (AOM) (experiment II). In experiment I, rats started on 1% Na-IP6 in drinking water 1 week prior to the carcinogen treatment showed a 34.7% decrease (P less than 0.01) in LIC compared to control carcinogen treatment group. A similar reduction in the incidence of LIC was also observed in experiment II, wherein Na-IP6 supplementation was started 2 weeks following the last dose of the carcinogen. Comparison of the incidence of mitosis in the colonic crypts of the animals in different groups show that animals on AOM + IP6 demonstrate a significantly lower (P less than 0.001) mitotic rate than those receiving AOM only. Pilot studies of free radical generation demonstrate a reduction in .OH radical formation by Na-IP6. Further studies to expand this pilot data and to understand the mechanism of IP6 mediated LIC suppression are needed for it may have significance in our strategies for LIC control. | lld:pubmed |
| pubmed-article:2833366 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2833366 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833366 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2833366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2833366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833366 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2833366 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2833366 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:2833366 | pubmed:author | pubmed-author:ShamsuddinA... | lld:pubmed |
| pubmed-article:2833366 | pubmed:author | pubmed-author:UllahAA | lld:pubmed |
| pubmed-article:2833366 | pubmed:author | pubmed-author:ElsayedA MAM | lld:pubmed |
| pubmed-article:2833366 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2833366 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2833366 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2833366 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2833366 | pubmed:pagination | 577-80 | lld:pubmed |
| pubmed-article:2833366 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
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| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
| pubmed-article:2833366 | pubmed:meshHeading | pubmed-meshheading:2833366-... | lld:pubmed |
| pubmed-article:2833366 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2833366 | pubmed:articleTitle | Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate. | lld:pubmed |
| pubmed-article:2833366 | pubmed:affiliation | Department of Pathology, University of Maryland School of Medicine, Baltimore 21201. | lld:pubmed |
| pubmed-article:2833366 | pubmed:publicationType | Journal Article | lld:pubmed |
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