| pubmed-article:2808515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2808515 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2808515 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2808515 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:2808515 | lifeskim:mentions | umls-concept:C0007709 | lld:lifeskim |
| pubmed-article:2808515 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:2808515 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2808515 | lifeskim:mentions | umls-concept:C0332221 | lld:lifeskim |
| pubmed-article:2808515 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2808515 | pubmed:dateCreated | 1989-12-5 | lld:pubmed |
| pubmed-article:2808515 | pubmed:abstractText | We report the interaction between a human centromere antigen and an alphoid DNA, a human centromeric satellite DNA, which consists of 170-bp repeating units. A cloned alphoid DNA fragment incubated with a HeLa cell nuclear extract is selectively immunoprecipitated by the anticentromere sera from scleroderma patients. Immunoprecipitation of the DNA made by primer extension defines the 17-bp segment on the alphoid DNA that is required for formation of DNA-antigen complex. On the other hand, when proteins bound to the biotinylated alphoid DNA carrying the 17-bp motif are recovered by streptavidin agarose and immunoblotted, the 80-kD centromere antigen (CENP-B) is detected. DNA binding experiments for proteins immunoprecipitated with anticentromere serum, separated by gel electrophoresis, and transferred to a membrane strongly suggest that the 80-kD antigen specifically binds to the DNA fragment with the 17-bp motif. The 17-bp motif is termed the "CENP-B box." Alphoid monomers with the CENP-B box are found in all the known alphoid subclasses, with varying frequencies, except the one derived from the Y chromosome so far cloned. These results imply that the interaction of the 80-kD centromere antigen with the CENP-B box in the alphoid repeats may play some crucial role in the formation of specified structure and/or function of human centromere. | lld:pubmed |
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| pubmed-article:2808515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2808515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2808515 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2808515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2808515 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2808515 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:2808515 | pubmed:author | pubmed-author:OkazakiTT | lld:pubmed |
| pubmed-article:2808515 | pubmed:author | pubmed-author:MasukataHH | lld:pubmed |
| pubmed-article:2808515 | pubmed:author | pubmed-author:MusaJJ | lld:pubmed |
| pubmed-article:2808515 | pubmed:author | pubmed-author:MasumotoHH | lld:pubmed |
| pubmed-article:2808515 | pubmed:author | pubmed-author:NozakiNN | lld:pubmed |
| pubmed-article:2808515 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2808515 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:2808515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2808515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2808515 | pubmed:pagination | 1963-73 | lld:pubmed |
| pubmed-article:2808515 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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