| pubmed-article:2787245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2787245 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2787245 | lifeskim:mentions | umls-concept:C0812382 | lld:lifeskim |
| pubmed-article:2787245 | lifeskim:mentions | umls-concept:C1415692 | lld:lifeskim |
| pubmed-article:2787245 | lifeskim:mentions | umls-concept:C1505203 | lld:lifeskim |
| pubmed-article:2787245 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:2787245 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2787245 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:2787245 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2787245 | pubmed:dateCreated | 1989-8-16 | lld:pubmed |
| pubmed-article:2787245 | pubmed:abstractText | Transcription of the human haptoglobin (Hp) gene is induced by interleukin-6 (IL-6) in the human hepatoma cell line Hep3B. Cis-acting elements responsible for this response are localized within the first 186 bp of the 5'-flanking region. Site-specific mutants of the Hp promoter fused to the chloramphenicol acetyl transferase (CAT) gene were analysed by transient transfection into uninduced and IL-6-treated Hep3B cells. We identified three regions, A, B and C, defined by mutation, which are important for the IL-6 response. Band shift experiments using nuclear extracts from untreated or IL-6-treated cells revealed the presence of IL-6-inducible DNA binding activities when DNA fragments containing the A or the C sequences were used. Competition experiments showed that both sequences bind to the same nuclear factors. Polymers of oligonucleotides containing either the A or the C regions confer IL-6 responsiveness to a truncated SV40 promoter. The B region forms several complexes with specific DNA-binding proteins different from those which bind to the A and C region. The B region complexes are identical in nuclear extracts from IL-6-treated and untreated cells. While important for IL-6 induction in the context of the haptoglobin promoter, the B site does not confer IL-6 inducibility to the SV40 promoter. Our results indicate that the IL-6 response of the haptoglobin promoter is dependent on the presence of multiple, partly redundant, cis-acting elements. | lld:pubmed |
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| pubmed-article:2787245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2787245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2787245 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2787245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2787245 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2787245 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:2787245 | pubmed:author | pubmed-author:CorteseRR | lld:pubmed |
| pubmed-article:2787245 | pubmed:author | pubmed-author:OlivieroSS | lld:pubmed |
| pubmed-article:2787245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2787245 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:2787245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2787245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2787245 | pubmed:pagination | 1145-51 | lld:pubmed |
| pubmed-article:2787245 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2787245 | pubmed:meshHeading | pubmed-meshheading:2787245-... | lld:pubmed |
| pubmed-article:2787245 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2787245 | pubmed:articleTitle | The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. | lld:pubmed |
| pubmed-article:2787245 | pubmed:affiliation | European Molecular Biology Laboratory, Heidelberg, FRG. | lld:pubmed |
| pubmed-article:2787245 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2787245 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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