| pubmed-article:2785856 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2785856 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:2785856 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2785856 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:2785856 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:2785856 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:2785856 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2785856 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2785856 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2785856 | pubmed:dateCreated | 1989-6-26 | lld:pubmed |
| pubmed-article:2785856 | pubmed:abstractText | We have devised a sensitive means to assess the anti-tumor effect of cytokines that act via the mobilization of host-mediated defenses. This assay involves transfecting malignant cells to produce a specific cytokine (in this case, IL-4) and measuring the ability of transfectants to form tumors alone and when mixed with a variety of nontransfected tumor cells. In this way, we have identified a potent, non-cell autonomous, anti-tumor effect of IL-4 which is effective against a wide range of tumor cell types in vivo. The effect is reversed by anti-IL-4 antibody, correlates closely with levels of IL-4 production, and is evident in nu/nu mice. The anti-tumor effect seems to be mediated by an inflammatory infiltrate composed of eosinophils and macrophages. | lld:pubmed |
| pubmed-article:2785856 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2785856 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2785856 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2785856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2785856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2785856 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2785856 | pubmed:month | May | lld:pubmed |
| pubmed-article:2785856 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2785856 | pubmed:author | pubmed-author:LederPP | lld:pubmed |
| pubmed-article:2785856 | pubmed:author | pubmed-author:PattengaleP... | lld:pubmed |
| pubmed-article:2785856 | pubmed:author | pubmed-author:TepperR IRI | lld:pubmed |
| pubmed-article:2785856 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2785856 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:2785856 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:2785856 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2785856 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2785856 | pubmed:pagination | 503-12 | lld:pubmed |
| pubmed-article:2785856 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2785856 | pubmed:meshHeading | pubmed-meshheading:2785856-... | lld:pubmed |
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| pubmed-article:2785856 | pubmed:meshHeading | pubmed-meshheading:2785856-... | lld:pubmed |
| pubmed-article:2785856 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2785856 | pubmed:articleTitle | Murine interleukin-4 displays potent anti-tumor activity in vivo. | lld:pubmed |
| pubmed-article:2785856 | pubmed:affiliation | Department of Genetics, Harvard Medical School, Boston, Massachusetts. | lld:pubmed |
| pubmed-article:2785856 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2785856 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2785856 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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