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pubmed-article:2776963pubmed:dateCreated1989-10-23lld:pubmed
pubmed-article:2776963pubmed:abstractTextThe secretion of growth hormone (GH) is abnormal in genetically obese Zucker rats. Measurements of pulsatile GH release and circulating GH levels in lean (Fa/?) and obese (fa/fa) rats have shown that both are reduced in the latter. We have studied pituitary GH gene expression in order to understand the role of GH synthesis in this abnormality. Obese animals have lower pituitary GH mRNA levels than lean controls. Within each genotype a sex difference was observed with the female animals having lower GH mRNA levels than the males. It is unlikely that the GH abnormality is due to a generalized pituitary defect because prolactin mRNA levels were the same in all four groups of rats.lld:pubmed
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pubmed-article:2776963pubmed:authorpubmed-author:AhmadIIlld:pubmed
pubmed-article:2776963pubmed:authorpubmed-author:StegglesA WAWlld:pubmed
pubmed-article:2776963pubmed:authorpubmed-author:CarrilloA JAJlld:pubmed
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pubmed-article:2776963pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2776963pubmed:year1989lld:pubmed
pubmed-article:2776963pubmed:articleTitleObesity- and sex-related alterations in growth hormone messenger RNA levels.lld:pubmed
pubmed-article:2776963pubmed:affiliationDepartment of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown 44272.lld:pubmed
pubmed-article:2776963pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2776963pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed