| pubmed-article:2764122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2764122 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:2764122 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2764122 | lifeskim:mentions | umls-concept:C2256468 | lld:lifeskim |
| pubmed-article:2764122 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:2764122 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2764122 | pubmed:issue | 2 Pt 2 | lld:pubmed |
| pubmed-article:2764122 | pubmed:dateCreated | 1989-9-14 | lld:pubmed |
| pubmed-article:2764122 | pubmed:abstractText | To evaluate further the role of adenosine in the transmission of tubuloglomerular feedback signals, we studied the effects of an adenosine receptor antagonist and an adenosine A1-receptor agonist on feedback-mediated changes in stop-flow pressure (SFP). In orthograde perfusion experiments conducted in anesthetized rats, systemic administration of the adenosine receptor blocker 1,3-dipropyl-8-sulfophenylxanthine (PSPX) did not inhibit feedback responses. Control SFP feedback responses averaged 9.7 +/- 0.65 before and 8.6 +/- 0.55 mmHg during systemic infusion of the receptor blocker. In retrograde perfusion experiments, intratubular administration of the A1 agonist (360 nM) N6-cyclopentyladenosine (CPA), added to a hypotonic solution, markedly enhanced feedback responses. This effect was completely prevented by coinfusion of PSPX. Addition of 10 mM of the antagonist to the CPA-containing solution attenuated SFP feedback responses to less than 1 mmHg (delta = 0.44 +/- 0.50). Furthermore, PSPX also inhibited feedback responses obtained with an isotonic solution alone. Furosemide, which has been shown to block normal SFP responses obtained with isotonic solutions, failed to block CPA-induced decreases in SFP. These data demonstrate that intraluminal administration of an adenosine A1 analogue causes feedback-mediated decreases in SFP and therefore support a role for adenosine receptors in the signal transmission pathway. | lld:pubmed |
| pubmed-article:2764122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2764122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2764122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2764122 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2764122 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2764122 | pubmed:author | pubmed-author:FrancoMM | lld:pubmed |
| pubmed-article:2764122 | pubmed:author | pubmed-author:NavarL GLG | lld:pubmed |
| pubmed-article:2764122 | pubmed:author | pubmed-author:BellP DPD | lld:pubmed |
| pubmed-article:2764122 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2764122 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:2764122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2764122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2764122 | pubmed:pagination | F231-6 | lld:pubmed |
| pubmed-article:2764122 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2764122 | pubmed:meshHeading | pubmed-meshheading:2764122-... | lld:pubmed |
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| pubmed-article:2764122 | pubmed:meshHeading | pubmed-meshheading:2764122-... | lld:pubmed |
| pubmed-article:2764122 | pubmed:meshHeading | pubmed-meshheading:2764122-... | lld:pubmed |
| pubmed-article:2764122 | pubmed:meshHeading | pubmed-meshheading:2764122-... | lld:pubmed |
| pubmed-article:2764122 | pubmed:meshHeading | pubmed-meshheading:2764122-... | lld:pubmed |
| pubmed-article:2764122 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2764122 | pubmed:articleTitle | Effect of adenosine A1 analogue on tubuloglomerular feedback mechanism. | lld:pubmed |
| pubmed-article:2764122 | pubmed:affiliation | Department of Physiology and Biophysics, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:2764122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2764122 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2764122 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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