| pubmed-article:2738645 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2738645 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2738645 | lifeskim:mentions | umls-concept:C0000768 | lld:lifeskim |
| pubmed-article:2738645 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:2738645 | lifeskim:mentions | umls-concept:C0017636 | lld:lifeskim |
| pubmed-article:2738645 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:2738645 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:2738645 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2738645 | pubmed:dateCreated | 1989-7-28 | lld:pubmed |
| pubmed-article:2738645 | pubmed:abstractText | Human glioblastomas are highly malignant intracranial tumors, some of which demonstrate amplification of the epidermal growth factor-receptor (EGF-R) gene. Overexpression of this gene is seen in the majority of primary tumors; however, the role of the EGF-R gene in glial tumorigenesis is unknown. The authors explored the relationship between EGF-R gene expression and glioblastoma cell growth in vitro and in vivo and found that this level of EGF-R gene expression did not correlate with tumor cell growth either in soft agar or in the nude mouse. This suggests that the EGF-R gene is not involved in effecting direct growth stimulation in glial oncogenesis. Tumorigenesis involves differentiation arrest; therefore, the expression of several proto-oncogenes in neuroectodermal tumors was investigated to evaluate the potential involvement of the EGF-R gene in glial differentiation. A nonoverlapping expression of the N-myc and EGF-R genes was found in neuronal-derived and glial-derived tumors, respectively. This suggests that the EGF-R gene may be involved in differentiation or its arrest in glia. | lld:pubmed |
| pubmed-article:2738645 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2738645 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2738645 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2738645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2738645 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2738645 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2738645 | pubmed:issn | 0022-3085 | lld:pubmed |
| pubmed-article:2738645 | pubmed:author | pubmed-author:HattonJ DJD | lld:pubmed |
| pubmed-article:2738645 | pubmed:author | pubmed-author:UH SHS | lld:pubmed |
| pubmed-article:2738645 | pubmed:author | pubmed-author:KelleyP YPY | lld:pubmed |
| pubmed-article:2738645 | pubmed:author | pubmed-author:ShewJ YJY | lld:pubmed |
| pubmed-article:2738645 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2738645 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:2738645 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2738645 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2738645 | pubmed:pagination | 83-90 | lld:pubmed |
| pubmed-article:2738645 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:meshHeading | pubmed-meshheading:2738645-... | lld:pubmed |
| pubmed-article:2738645 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2738645 | pubmed:articleTitle | Proto-oncogene abnormalities and their relationship to tumorigenicity in some human glioblastomas. | lld:pubmed |
| pubmed-article:2738645 | pubmed:affiliation | Division of Neurological Surgery, University of California, San Diego. | lld:pubmed |
| pubmed-article:2738645 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2738645 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2738645 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2738645 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2738645 | lld:pubmed |
