| pubmed-article:2662974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2662974 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:2662974 | lifeskim:mentions | umls-concept:C0034580 | lld:lifeskim |
| pubmed-article:2662974 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2662974 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2662974 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2662974 | pubmed:dateCreated | 1989-8-8 | lld:pubmed |
| pubmed-article:2662974 | pubmed:abstractText | A marked increase in immunoreactive endothelin was observed in rat serum collected within 10-15 min after infusion of endotoxin. Endothelin level was 117 +/- 11.5 pg/ml (mean +/- S.E., N = 4) in rats exposed to endotoxin as compared with undetectable levels (less than 2 pg/ml, N = 4) in controls. We have also observed a significant stimulation of endothelin-release by endotoxin from cultured bovine transformed thoractic aortic endothelial cells at concentrations of endotoxin ranging between 0.1 and 10.0 micrograms/ml. Serum was indispensable for the stimulating effect of endotoxin, although serum itself did not show any effect at the concentration used (1%). These results suggest that endothelin plays an important role in mediation of pathophysiological responses caused by endotoxin. The levels of endothelin were measured by radioimmunoassay with high sensitivity. | lld:pubmed |
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| pubmed-article:2662974 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2662974 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2662974 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2662974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2662974 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2662974 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2662974 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:2662974 | pubmed:author | pubmed-author:SugiuraMM | lld:pubmed |
| pubmed-article:2662974 | pubmed:author | pubmed-author:InagamiTT | lld:pubmed |
| pubmed-article:2662974 | pubmed:author | pubmed-author:KouMM | lld:pubmed |
| pubmed-article:2662974 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2662974 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:2662974 | pubmed:volume | 161 | lld:pubmed |
| pubmed-article:2662974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2662974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2662974 | pubmed:pagination | 1220-7 | lld:pubmed |
| pubmed-article:2662974 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2662974 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2662974 | pubmed:articleTitle | Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay. | lld:pubmed |
| pubmed-article:2662974 | pubmed:affiliation | Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232. | lld:pubmed |
| pubmed-article:2662974 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2662974 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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