| pubmed-article:265565 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:265565 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:265565 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:265565 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:265565 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:265565 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:265565 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:265565 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:265565 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:265565 | pubmed:dateCreated | 1977-5-12 | lld:pubmed |
| pubmed-article:265565 | pubmed:abstractText | This investigation demonstrated that antigenic expression in liposomal model membranes may be markedly influenced by phospholipid composition. Incorporation of dinitrophenylaminocaproylphosphatidylethanolamine (Dnp-Cap-PE) into egg lecithin/cholesterol/dicetylphosphate bilayers did not significantly enhance the response of AKR mice to this synthetic amphipathic antigen. In contrast, the immunogenicity of Dnp-Cap-PE was increased (as measured by either plaque-forming cell frequency of hemagglutination titer) after its insertion into liposomes prepared with beef sphingomyelin instead of egg lecithin. We also show that the response to the Dnp-Cap determinant can be stimulated by the presence of lipid A in the same bilayers without altering the relative immunogenic potency of the sphingomyelin and lecithin liposomes; similarly, incorporation of this mitogen into sphingomyelin liposomes produced a greater polyclonal (nonspecific) response. The response to Dnp-Cap-PE-sensitized liposomes (with or without lipid A) prepared with a series of synthetic phosphatidylcholines (distearoyl-, dipalmitoyl-, dimyristoyl-, dilauroyl-, dioleoyl-) suggests a direct correlation between liposomal immunogenicity and transition temperature of the phospholipid. | lld:pubmed |
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| pubmed-article:265565 | pubmed:language | eng | lld:pubmed |
| pubmed-article:265565 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:265565 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:265565 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:265565 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:265565 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:265565 | pubmed:author | pubmed-author:DanceyG FGF | lld:pubmed |
| pubmed-article:265565 | pubmed:author | pubmed-author:YasudaTT | lld:pubmed |
| pubmed-article:265565 | pubmed:author | pubmed-author:KinskyS CSC | lld:pubmed |
| pubmed-article:265565 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:265565 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:265565 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:265565 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:265565 | pubmed:pagination | 1234-6 | lld:pubmed |
| pubmed-article:265565 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:265565 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:265565 | pubmed:articleTitle | Immunogenicity of liposomal model membranes in mice: dependence on phospholipid composition. | lld:pubmed |
| pubmed-article:265565 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:265565 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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