| pubmed-article:2649252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2649252 | lifeskim:mentions | umls-concept:C0014181 | lld:lifeskim |
| pubmed-article:2649252 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:2649252 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:2649252 | lifeskim:mentions | umls-concept:C2347858 | lld:lifeskim |
| pubmed-article:2649252 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2649252 | pubmed:dateCreated | 1989-5-19 | lld:pubmed |
| pubmed-article:2649252 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2649252 | pubmed:abstractText | In fission yeast, the initiation of mitosis is regulated by a control network that integrates the opposing activities of mitotic inducers and inhibitors. To evaluate whether this control system is likely to be conserved among eukaryotes, we have investigated whether a similar mitotic control operates in the distantly related budding yeast S. cerevisiae. We have found that the protein kinase encoded by the mitotic inhibitor gene wee1+ of fission yeast, which acts to delay mitosis, is able also to delay the initiation of mitosis when expressed in S. cerevisiae. The wee1+ activity is counteracted in S. cerevisiae by the gene product of MIH1, a newly identified gene capable of encoding a protein of MW 54,000, which is a structural and functional homolog of the cdc25+ mitotic inducer of fission yeast. Expression of wee1+ in a mih1- strain prevents the initiation of mitosis. These data indicate that important features of the cdc25+-wee1+ mitotic control network identified in S. pombe are conserved in S. cerevisiae, and therefore are also likely to be generally conserved among eukaryotic organisms. | lld:pubmed |
| pubmed-article:2649252 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2649252 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2649252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2649252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2649252 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2649252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2649252 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2649252 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2649252 | pubmed:author | pubmed-author:RuddC JCJ | lld:pubmed |
| pubmed-article:2649252 | pubmed:author | pubmed-author:RussellPP | lld:pubmed |
| pubmed-article:2649252 | pubmed:author | pubmed-author:MorenoSS | lld:pubmed |
| pubmed-article:2649252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2649252 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:2649252 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:2649252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2649252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2649252 | pubmed:pagination | 295-303 | lld:pubmed |
| pubmed-article:2649252 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:meshHeading | pubmed-meshheading:2649252-... | lld:pubmed |
| pubmed-article:2649252 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2649252 | pubmed:articleTitle | Conservation of mitotic controls in fission and budding yeasts. | lld:pubmed |
| pubmed-article:2649252 | pubmed:affiliation | Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037. | lld:pubmed |
| pubmed-article:2649252 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2649252 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2649252 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2649252 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:855052 | entrezgene:pubmed | pubmed-article:2649252 | lld:entrezgene |
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