| pubmed-article:2645713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2645713 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2645713 | lifeskim:mentions | umls-concept:C0022671 | lld:lifeskim |
| pubmed-article:2645713 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:2645713 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
| pubmed-article:2645713 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:2645713 | lifeskim:mentions | umls-concept:C0855279 | lld:lifeskim |
| pubmed-article:2645713 | lifeskim:mentions | umls-concept:C0205175 | lld:lifeskim |
| pubmed-article:2645713 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2645713 | pubmed:dateCreated | 1989-4-3 | lld:pubmed |
| pubmed-article:2645713 | pubmed:abstractText | The significance of the antiglobulin crossmatch in the cyclosporine era remains controversial. Over an 11-month period, 124 recipients of cadaveric renal allografts (109 primary, 15 nonprimary) were retrospectively crossmatched via the antiglobulin technique. Criteria for recipient selection for transplantation included a negative T lymphocytotoxic (CDC) crossmatch for current and historical sera. Fourteen patients (11.3%) underwent transplantation in the setting of a negative T and positive antiglobulin crossmatch. The patient group included 10 female and 4 male patients with a mean age of 43.8 years. All but one patient received a primary transplant, and current sera were positive in the antiglobulin crossmatch in all cases. The mean HLA-ABDR match was 1.4 (range 0-4). Preoperative PRA titers ranged from 0 to 80% (mean 18.3%). All patients underwent successful renal transplantation with quadruple immunosuppression consisting of prednisone, azathioprine, and the sequential use of MALG/cyclosporine. There were no episodes of hyperacute rejection. However, 10 patients (71.4%) experienced acute rejection, including 7 episodes within 4 days of transplant. Early rejection was significantly more common in patients with a positive antiglobulin test (50% vs. 20.9%, P less than 0.05). The mean one-month serum creatinine was 1.7 mg/dl. Actual patient and allograft survival are 92.9% and 85.7%, respectively. Risk factors for a positive antiglobulin crossmatch included female sex and prior sensitization as measured by PRA. Although these patients represent a high-risk group for early rejection, no adverse effect on patient or graft survival was noted with quadruple immunotherapy. In conclusion, a positive antiglobulin crossmatch is no longer a contraindication to renal transplantation with current immunosuppressive strategies. | lld:pubmed |
| pubmed-article:2645713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2645713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2645713 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2645713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2645713 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2645713 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:SollingerH... | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:BelzerF OFO | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:MasonBB | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:D'AlessandroA... | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:StrattaR JRJ | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:PirschJ DJD | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:KalayogluMM | lld:pubmed |
| pubmed-article:2645713 | pubmed:author | pubmed-author:LorentzenD... | lld:pubmed |
| pubmed-article:2645713 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2645713 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:2645713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2645713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2645713 | pubmed:pagination | 282-6 | lld:pubmed |
| pubmed-article:2645713 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:2645713 | pubmed:meshHeading | pubmed-meshheading:2645713-... | lld:pubmed |
| pubmed-article:2645713 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2645713 | pubmed:articleTitle | Cadaveric renal transplantation with quadruple immunosuppression in patients with a positive antiglobulin crossmatch. | lld:pubmed |
| pubmed-article:2645713 | pubmed:affiliation | Department of Surgery, University of Wisconsin School of Medicine, Madison 53792. | lld:pubmed |
| pubmed-article:2645713 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2645713 | lld:pubmed |
