| pubmed-article:2629939 | pubmed:abstractText | One of the most important concepts in the understanding of the biology of squamous cell carcinoma of the head and neck is "multicentric cancer" as proposed by Slaughter et al. in 1953. With prolonged survival as a result of improved cancer therapy, the possibility of a second primary lesion should always be kept in mind during patient follow-up. A late or unusual metastasis in a patient with upper aerodigestive malignancy should be suspected of having a new primary carcinoma. In the last 12 months, we have treated 72 patients with upper aerodigestive malignancy. 5 of them had a history of previous squamous cell carcinoma of head and neck treated 6-13 years before. Probable etiopathogenic factors are discussed. | lld:pubmed |
