| pubmed-article:2575380 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:2575380 | lifeskim:mentions | umls-concept:C1527240 | lld:lifeskim |
| pubmed-article:2575380 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2575380 | pubmed:dateCreated | 1990-2-13 | lld:pubmed |
| pubmed-article:2575380 | pubmed:abstractText | A novel 6-substituted acyclouridine derivative, 1-[(2-hydroxy-ethoxy) methyl]-6-phenylthiothymine (HEPT), has proved to be a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro. HEPT inhibits HIV-1 replication in various T4 cell cultures as well as peripheral blood lymphocytes and macrophages. The 50% antiviral effective concentration for HIV-1 (HTLV-IIIB) in MT-4 cells is 7.0 microM, while the 50% cytotoxic concentration for mock-infected MT-4 cells is 740 microM. Although HEPT is inhibitory to various strains of HIV-1, it has no effect on the replication of other retroviruses including HIV type 2. In contrast with the dideoxynucleoside (i.e. azidothymidine) 5'-triphosphates, the triphosphate of HEPT does not interact with HIV-1 reverse transcriptase. The mechanism of action of HEPT remains subject of further study. | lld:pubmed |
| pubmed-article:2575380 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2575380 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2575380 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2575380 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2575380 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2575380 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:TanakaHH | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:PauwelsRR | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:De ClercqEE | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:BabbLL | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:ScholeJJ | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:WalkerR TRT | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:MiyasakaTT | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:NakashimaHH | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:BalzariniJJ | lld:pubmed |
| pubmed-article:2575380 | pubmed:author | pubmed-author:PernoC FCF | lld:pubmed |
| pubmed-article:2575380 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2575380 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:2575380 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:2575380 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2575380 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2575380 | pubmed:pagination | 1375-81 | lld:pubmed |
| pubmed-article:2575380 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2575380 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2575380 | pubmed:articleTitle | Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative. | lld:pubmed |
| pubmed-article:2575380 | pubmed:affiliation | Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium. | lld:pubmed |
| pubmed-article:2575380 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2575380 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2575380 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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