| pubmed-article:2573979 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2573979 | lifeskim:mentions | umls-concept:C0376180 | lld:lifeskim |
| pubmed-article:2573979 | lifeskim:mentions | umls-concept:C1882874 | lld:lifeskim |
| pubmed-article:2573979 | lifeskim:mentions | umls-concept:C0061132 | lld:lifeskim |
| pubmed-article:2573979 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2573979 | lifeskim:mentions | umls-concept:C2610946 | lld:lifeskim |
| pubmed-article:2573979 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2573979 | pubmed:dateCreated | 1990-1-8 | lld:pubmed |
| pubmed-article:2573979 | pubmed:abstractText | In the present study the effects of gastrin-releasing peptide (GRP1-27), its C-terminal decapeptide neuromedin-C (GRP18-27) and the related peptide neuromedin-B were examined on the secretion of gastrin and somatostatin-like immunoreactivity (SLI) from the isolated perfused rat stomach at intraluminal pH 7 or pH 2. GRP1-27 and GRP18-27 stimulated gastrin secretion equally effective at concentrations of 10(-10), 10(-9), 10(-8), 10(-7) and 10(6)M at luminal pH 7. In addition neuromedin-B was tested at 10(-11), 10(-10), 10(-8) and 10(-6)M and it increased gastrin release similar to equimolar doses of GRP18-27. At luminal pH 2 GRP1-27 stimulated gastrin secretion at 10(-9), 10(-8), 10(-7) and 10(-6)M while GRP18-27 was only effective at 10(-8) and 10(-7)M. Neuromedin-B elicited a gastrin increase at 10(-8)M similar to GRP18-27 and also at 10(-6)M. All three peptides had no significant effect on SLI release at luminal pH 7. At luminal pH 2 GRP1-27 at 10(-9)M and 10(-6)M and GRP18-27 and neuromedin-B at 10(-10)M elicited a significant stimulation of SLI secretion. These data demonstrate that all three bombesin-like peptides GRP1-27, GRP18-27 and neuromedin-B can stimulate gastrin release at either a neutral or an acidic luminal pH, while SLI release is affected only at an acidic intragastric milieu. This suggests that all three forms of bombesin-like peptides are good candidates for the peptidergic regulation of gastrin release in the rat stomach, while their role in somatostatin release seems to be more restricted. | lld:pubmed |
| pubmed-article:2573979 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2573979 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2573979 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2573979 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2573979 | pubmed:issn | 0044-2771 | lld:pubmed |
| pubmed-article:2573979 | pubmed:author | pubmed-author:ClassenMM | lld:pubmed |
| pubmed-article:2573979 | pubmed:author | pubmed-author:SchusdziarraV... | lld:pubmed |
| pubmed-article:2573979 | pubmed:author | pubmed-author:MadausSS | lld:pubmed |
| pubmed-article:2573979 | pubmed:author | pubmed-author:SeufferleinTT | lld:pubmed |
| pubmed-article:2573979 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2573979 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:2573979 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2573979 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2573979 | pubmed:pagination | 449-54 | lld:pubmed |
| pubmed-article:2573979 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:2573979 | pubmed:meshHeading | pubmed-meshheading:2573979-... | lld:pubmed |
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| pubmed-article:2573979 | pubmed:meshHeading | pubmed-meshheading:2573979-... | lld:pubmed |
| pubmed-article:2573979 | pubmed:meshHeading | pubmed-meshheading:2573979-... | lld:pubmed |
| pubmed-article:2573979 | pubmed:meshHeading | pubmed-meshheading:2573979-... | lld:pubmed |
| pubmed-article:2573979 | pubmed:meshHeading | pubmed-meshheading:2573979-... | lld:pubmed |
| pubmed-article:2573979 | pubmed:meshHeading | pubmed-meshheading:2573979-... | lld:pubmed |
| pubmed-article:2573979 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2573979 | pubmed:articleTitle | Effect of gastrin-releasing peptide (GRP1-27), neuromedin-C (GRP18-27), and neuromedin-B on gastrin and somatostatin secretion from the rat stomach. | lld:pubmed |
| pubmed-article:2573979 | pubmed:affiliation | Department of Internal Medicine II, Technical University of Munich, Germany. | lld:pubmed |
| pubmed-article:2573979 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2573979 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
