| pubmed-article:2564203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2564203 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:2564203 | lifeskim:mentions | umls-concept:C0074830 | lld:lifeskim |
| pubmed-article:2564203 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:2564203 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2564203 | pubmed:dateCreated | 1989-4-13 | lld:pubmed |
| pubmed-article:2564203 | pubmed:abstractText | The brain somatostatin (somatotropin release-inhibiting factor; SRIF) receptor was purified by affinity chromatographic techniques. A protein of 60 kDa could be purified from rat brain. The protein was eluted from a [D-Trp8]SRIF affinity column with either sodium acetate (pH 5.5) or free [D-Trp8]SRIF. The binding of the protein to the affinity column was prevented by free [D-Trp8]SRIF or the stable SRIF analogue SMS 201-996 but not by the inactive somatostatin 28-(1-14). The purified receptor could be covalently labeled by the 125I-labeled SRIF analogue CGP 23996. Excess [D-Trp8]SRIF blocked the binding of 125I-labeled CGP 23996 to the purified receptor, but somatostatin 28-(1-14) did not affect the binding. A 60-kDa protein was also purified from the anterior pituitary cell line AtT-20, which has a high expression of SRIF receptors. In contrast, no 60-kDa protein could be purified from CHO cells, which have no detectable SRIF receptors. These findings present evidence for the purification of the SRIF receptor. | lld:pubmed |
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| pubmed-article:2564203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2564203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2564203 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2564203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2564203 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2564203 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2564203 | pubmed:author | pubmed-author:JohnsonKK | lld:pubmed |
| pubmed-article:2564203 | pubmed:author | pubmed-author:ReisineTT | lld:pubmed |
| pubmed-article:2564203 | pubmed:author | pubmed-author:ThermosKK | lld:pubmed |
| pubmed-article:2564203 | pubmed:author | pubmed-author:HeH THT | lld:pubmed |
| pubmed-article:2564203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2564203 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2564203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2564203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2564203 | pubmed:pagination | 1480-4 | lld:pubmed |
| pubmed-article:2564203 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2564203 | pubmed:meshHeading | pubmed-meshheading:2564203-... | lld:pubmed |
| pubmed-article:2564203 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2564203 | pubmed:articleTitle | Purification of a putative brain somatostatin receptor. | lld:pubmed |
| pubmed-article:2564203 | pubmed:affiliation | Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104. | lld:pubmed |
| pubmed-article:2564203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2564203 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2564203 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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