| pubmed-article:2562846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C0040287 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C0220927 | lld:lifeskim |
| pubmed-article:2562846 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:2562846 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2562846 | pubmed:dateCreated | 1989-2-9 | lld:pubmed |
| pubmed-article:2562846 | pubmed:abstractText | Evidence was sought on the tissue distribution of Mlsa determinants, a class of cell-associated non-H-2 alloantigens that is highly immunogenic for unprimed T cells. Whereas normal CD4+ T cells and an Mlsa-reactive T hybridoma gave strong responses to Mlsa-positive stimulator populations containing Ig+ B cells, anti-Mlsa responses to B-depleted stimulators were almost undetectable. The B-depleted stimulators tested included Thy-1- spleen cells from mu-suppressed mice (mice treated with anti-mu antibody from birth) and J11d- preparations of spleen dendritic cells (DC) and peritoneal macrophages (M phi) from normal mice. Each of these populations was strongly immunogenic for allo-H-2-reactive T cells. The failure to detect Mlsa determinants on Ig- APC, i.e., M phi and DC, suggests that Mlsa determinants are not typical H-2-associated peptides. The data are more compatible with a model in which Mlsa determinants represent (or form part of) an integral cell membrane molecule expressed largely, and perhaps exclusively, on B cells. T cells might recognize these molecules only in native form, "processed" Mlsa determinants being nonimmunogenic. Consistent with this possibility, no evidence was found that Mlsa-negative B cells could absorb Mlsa determinants from Mlsa-positive B cells in a chimeric environment. | lld:pubmed |
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| pubmed-article:2562846 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2562846 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2562846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2562846 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2562846 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2562846 | pubmed:author | pubmed-author:SprentJJ | lld:pubmed |
| pubmed-article:2562846 | pubmed:author | pubmed-author:WebbS RSR | lld:pubmed |
| pubmed-article:2562846 | pubmed:author | pubmed-author:OkamotoAA | lld:pubmed |
| pubmed-article:2562846 | pubmed:author | pubmed-author:RowRR | lld:pubmed |
| pubmed-article:2562846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2562846 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2562846 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:2562846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2562846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2562846 | pubmed:pagination | 1-12 | lld:pubmed |
| pubmed-article:2562846 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2562846 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2562846 | pubmed:articleTitle | Restricted tissue distribution of Mlsa determinants. Stimulation of Mlsa-reactive T cells by B cells but not by dendritic cells or macrophages. | lld:pubmed |
| pubmed-article:2562846 | pubmed:affiliation | Research Institute of Scripps Clinic, La Jolla, California 92037. | lld:pubmed |
| pubmed-article:2562846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2562846 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2562846 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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