| pubmed-article:2544103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C1367482 | lld:lifeskim |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:2544103 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:2544103 | pubmed:issue | 6 Pt 2 | lld:pubmed |
| pubmed-article:2544103 | pubmed:dateCreated | 1989-7-18 | lld:pubmed |
| pubmed-article:2544103 | pubmed:abstractText | Previous reports have suggested that organic calcium antagonists only partially inhibit the renal hemodynamic actions of angiotensin II (ANG II). This study tested the hypothesis that the calcium antagonist-sensitive component of ANG II-induced vasoconstriction is localized at a preglomerular site. Videomicroscopic measurements of vascular dimension were performed on in vitro blood-perfused juxtamedullary nephrons from captopril-treated rats. Under control conditions, afferent and efferent arteriolar diameters averaged 23.0 +/- 1.6 and 21.2 +/- 2.2 microns, respectively. Topical application of 0.1 nM ANG II decreased the diameters of afferent (-17 +/- 2%) and efferent (-15 +/- 3%) arterioles. Both 50 microM verapamil and 10 microM diltiazem dilated afferent arterioles. Verapamil also elicited a modest efferent vasodilation. In the presence of either verapamil or diltiazem, the effect of ANG II to decrease efferent diameter was sustained (-15 +/- 4%); however, the effect of ANG II on afferent diameter was abolished (-1 +/- 1%). These observations document differential influences of calcium channel blockers on ANG II-mediated vasoconstriction and suggest that the pre- and postglomerular vasoconstrictor actions of ANG II may occur through different calcium entry or mobilization mechanisms. | lld:pubmed |
| pubmed-article:2544103 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544103 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544103 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2544103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544103 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2544103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2544103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2544103 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2544103 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2544103 | pubmed:author | pubmed-author:NavarL GLG | lld:pubmed |
| pubmed-article:2544103 | pubmed:author | pubmed-author:CarminesP KPK | lld:pubmed |
| pubmed-article:2544103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2544103 | pubmed:volume | 256 | lld:pubmed |
| pubmed-article:2544103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2544103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2544103 | pubmed:pagination | F1015-20 | lld:pubmed |
| pubmed-article:2544103 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:meshHeading | pubmed-meshheading:2544103-... | lld:pubmed |
| pubmed-article:2544103 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2544103 | pubmed:articleTitle | Disparate effects of Ca channel blockade on afferent and efferent arteriolar responses to ANG II. | lld:pubmed |
| pubmed-article:2544103 | pubmed:affiliation | Department of Physiology and Biophysics, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:2544103 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2544103 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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