| pubmed-article:2537418 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2537418 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:2537418 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2537418 | lifeskim:mentions | umls-concept:C0358591 | lld:lifeskim |
| pubmed-article:2537418 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2537418 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:2537418 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:2537418 | lifeskim:mentions | umls-concept:C0740025 | lld:lifeskim |
| pubmed-article:2537418 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2537418 | pubmed:dateCreated | 1989-4-3 | lld:pubmed |
| pubmed-article:2537418 | pubmed:abstractText | The antisecretory and antiulcer activities of 2[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazole (AG-1749) were investigated in dogs and rats. AG-1749 inhibited both the (H+ + K+)-adenosine triphosphatase activity in canine gastric microsomes and dibutyryl cyclic AMP-stimulated acid formation in isolated canine parietal cells and suppressed the acid secretion stimulated by histamine, pentagastrin, bethanechol or a peptone meal in Heidenhain pouch dogs; the ID50 values were between 0.2 and 0.7 mg/kg p.o. AG-1749 inhibited both the histamine-stimulated and the basal acid secretion in pylorusligated rats and prevented water immersion stress or aspirin-induced gastric lesions and mepirizole or cysteamine-induced duodenal ulcers in rats; the ID50 values were between 0.3 to 3.6 mg/kg p.o. or i.d. Furthermore, AG-1749 prevented gastric lesions induced by absolute ethanol or acidified aspirin, and accelerated the healing of acetic acid-induced gastric or duodenal ulcers in rats. The inhibitory potency of AG-1749 in dogs was much the same as that of omeprazole and about half that of ranitidine. However, it was about 2 to 10 times more potent than omeprazole and 4 to 34 times more potent than ranitidine in rats. These results suggest that AG-1749 exerts prominent antiulcer activities mainly by suppressing acid secretion via an inhibition of a proton pump in gastric parietal cells and partly by protecting the gastrointestinal mucosa against various ulcerative stimuli. | lld:pubmed |
| pubmed-article:2537418 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2537418 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2537418 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2537418 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2537418 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:2537418 | pubmed:author | pubmed-author:NoharaAA | lld:pubmed |
| pubmed-article:2537418 | pubmed:author | pubmed-author:NakamuraNN | lld:pubmed |
| pubmed-article:2537418 | pubmed:author | pubmed-author:InatomiNN | lld:pubmed |
| pubmed-article:2537418 | pubmed:author | pubmed-author:MakiYY | lld:pubmed |
| pubmed-article:2537418 | pubmed:author | pubmed-author:NagayaHH | lld:pubmed |
| pubmed-article:2537418 | pubmed:author | pubmed-author:SatohHH | lld:pubmed |
| pubmed-article:2537418 | pubmed:author | pubmed-author:InadaII | lld:pubmed |
| pubmed-article:2537418 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2537418 | pubmed:volume | 248 | lld:pubmed |
| pubmed-article:2537418 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2537418 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2537418 | pubmed:pagination | 806-15 | lld:pubmed |
| pubmed-article:2537418 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2537418 | pubmed:meshHeading | pubmed-meshheading:2537418-... | lld:pubmed |
| pubmed-article:2537418 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2537418 | pubmed:articleTitle | Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. | lld:pubmed |
| pubmed-article:2537418 | pubmed:affiliation | Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan. | lld:pubmed |
| pubmed-article:2537418 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2537418 | pubmed:publicationType | In Vitro | lld:pubmed |
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