| pubmed-article:2535839 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2535839 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:2535839 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2535839 | lifeskim:mentions | umls-concept:C0007841 | lld:lifeskim |
| pubmed-article:2535839 | lifeskim:mentions | umls-concept:C0023775 | lld:lifeskim |
| pubmed-article:2535839 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2535839 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2535839 | pubmed:dateCreated | 1989-2-7 | lld:pubmed |
| pubmed-article:2535839 | pubmed:abstractText | Ceruloplasmin (CP) was found to inhibit xanthine oxidase and ferritin-dependent peroxidation of phospholipid liposomes, as evidenced by decreased malondialdehyde formation. Ceruloplasmin was also shown to inhibit superoxide-mediated mobilization of iron from ferritin, in a concentration-dependent manner, as measured spectrophotometrically using the iron(II) chelator bathophenanthroline sulfonate. Ceruloplasmin failed to function as a peroxyl radical-scavenging antioxidant as evidenced by its inability to inhibit free radical-initiated peroxidation of linoleic acid, suggesting that CP inhibited lipid peroxidation by affecting the availability of ferritin-derived iron. In addition, CP scavenged xanthine oxidase-derived superoxide as measured spectrophotometrically via its effect on cytochrome c reduction. However, the extent of the superoxide scavenging of CP did not quantitatively account for its effects on iron release, suggesting that CP inhibits superoxide-dependent mobilization of ferritin iron independently of its ability to scavenge superoxide. The effects of CP and apoferritin on iron-catalyzed lipid peroxidation in systems containing exogenously added ferrous iron was also investigated. In the absence of apoferritin, CP exhibited a concentration-dependent prooxidant effect. However, CP-dependent, iron-catalyzed lipid peroxidation was inhibited by the addition of apoferritin. Apoferritin did not function as a peroxyl radical-scavenging antioxidant but was shown to incorporate iron in the presence of CP. These data suggest that CP inhibits superoxide and ferritin-dependent lipid peroxidation largely via its ability to reincorporate reductively mobilized iron back into ferritin. | lld:pubmed |
| pubmed-article:2535839 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2535839 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2535839 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2535839 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2535839 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2535839 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2535839 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:2535839 | pubmed:author | pubmed-author:MillerD MDM | lld:pubmed |
| pubmed-article:2535839 | pubmed:author | pubmed-author:AustS DSD | lld:pubmed |
| pubmed-article:2535839 | pubmed:author | pubmed-author:ReidD ADA | lld:pubmed |
| pubmed-article:2535839 | pubmed:author | pubmed-author:SamokyszynV... | lld:pubmed |
| pubmed-article:2535839 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2535839 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:2535839 | pubmed:volume | 264 | lld:pubmed |
| pubmed-article:2535839 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2535839 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2535839 | pubmed:pagination | 21-6 | lld:pubmed |
| pubmed-article:2535839 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2535839 | pubmed:meshHeading | pubmed-meshheading:2535839-... | lld:pubmed |
| pubmed-article:2535839 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2535839 | pubmed:articleTitle | Inhibition of superoxide and ferritin-dependent lipid peroxidation by ceruloplasmin. | lld:pubmed |
| pubmed-article:2535839 | pubmed:affiliation | Biotechnology Center, Utah State University, Logan 84322-4430. | lld:pubmed |
| pubmed-article:2535839 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2535839 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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