pubmed-article:2531289 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2531289 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:2531289 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
pubmed-article:2531289 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:2531289 | lifeskim:mentions | umls-concept:C1447107 | lld:lifeskim |
pubmed-article:2531289 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:2531289 | pubmed:issue | 6248 | lld:pubmed |
pubmed-article:2531289 | pubmed:dateCreated | 1990-1-4 | lld:pubmed |
pubmed-article:2531289 | pubmed:abstractText | Hepatocyte growth factor (HGF) is the most potent mitogen for mature parenchymal hepatocytes in primary culture, and seems to be a hepatotrophic factor that acts as a trigger for liver regeneration after partial hepatectomy and liver injury. The partial purification and characterization of HGF have been reported. We have demonstrated that pure HGF from rat platelets is a new growth factor effective at concentrations as low as 1 ng ml-1. The effects of HGF and epidermal growth factor (EGF) are additive. The activity of HGF is not species-specific, although it does not stimulate growth in Swiss 3T3 fibroblasts. HGF has a relative molecular mass (Mr) of 82,000 and is a heterodimer composed of a large alpha-subunit of Mr 69,000 and a small beta-subunit of Mr 34,000. Here we report the amino-acid sequence of human HGF determined by complementary DNA cloning and the expression of biologically active human HGF from COS-1 cells transfected with cloned cDNA. The nucleotide sequence of the human HGF cDNA reveals that both alpha- and beta-chains are contained in a single open reading frame coding for a pre-pro precursor protein of 728 amino acids. | lld:pubmed |
pubmed-article:2531289 | pubmed:language | eng | lld:pubmed |
pubmed-article:2531289 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2531289 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2531289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2531289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2531289 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2531289 | pubmed:month | Nov | lld:pubmed |
pubmed-article:2531289 | pubmed:issn | 0028-0836 | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:SekiTT | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:ShimizuSS | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:HagiyaMM | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:TashiroKK | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:NishizawaTT | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:ShimonishiMM | lld:pubmed |
pubmed-article:2531289 | pubmed:author | pubmed-author:SugimuraAA | lld:pubmed |
pubmed-article:2531289 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2531289 | pubmed:day | 23 | lld:pubmed |
pubmed-article:2531289 | pubmed:volume | 342 | lld:pubmed |
pubmed-article:2531289 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2531289 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2531289 | pubmed:pagination | 440-3 | lld:pubmed |
pubmed-article:2531289 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:2531289 | pubmed:meshHeading | pubmed-meshheading:2531289-... | lld:pubmed |
pubmed-article:2531289 | pubmed:year | 1989 | lld:pubmed |
pubmed-article:2531289 | pubmed:articleTitle | Molecular cloning and expression of human hepatocyte growth factor. | lld:pubmed |
pubmed-article:2531289 | pubmed:affiliation | Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan. | lld:pubmed |
pubmed-article:2531289 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2531289 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:3082 | entrezgene:pubmed | pubmed-article:2531289 | lld:entrezgene |
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