| pubmed-article:2530579 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2530579 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2530579 | lifeskim:mentions | umls-concept:C0063710 | lld:lifeskim |
| pubmed-article:2530579 | lifeskim:mentions | umls-concept:C0443299 | lld:lifeskim |
| pubmed-article:2530579 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:2530579 | lifeskim:mentions | umls-concept:C1882932 | lld:lifeskim |
| pubmed-article:2530579 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:2530579 | pubmed:dateCreated | 1989-12-1 | lld:pubmed |
| pubmed-article:2530579 | pubmed:abstractText | Interleukin 1 (IL-1) is a polypeptide hormone that mediates a broad range of biological activities and interacts with surface receptors on numerous cell types. Equilibrium binding studies have identified a class of IL-1 receptors on T cells, fibroblasts, and epithelial cells that have 2- to 5-fold higher affinity than the receptors on bone marrow cells, pre-B cells, and macrophage cell lines. Affinity cross-linking with human 125I-labeled IL-1 alpha (125I-IL-1 alpha) labels an approximately 100-kDa protein on T cells and fibroblasts and an approximately 80-kDa protein on pre-B cells and macrophage cell lines. Monoclonal and polyclonal antibodies specific for the IL-1 receptor on T cells and fibroblasts block human 125I-IL-1 alpha binding to T cells, fibroblasts, and epithelial cells but cannot block IL-1 binding to bone marrow cells, pre-B cells, and macrophages. These antibodies immunoprecipitate the IL-1 receptor-human 125I-IL-1 alpha complex from T cells and fibroblasts but not from pre-B cells and macrophage cell lines. An S1 nuclease protection assay demonstrated that T cells and fibroblasts contain identical IL-1 receptor mRNA but that pre-B cells and macrophages do not contain this receptor mRNA. Taken together, the data demonstrate that mouse T cells, fibroblasts, and epithelial cells express an identical IL-1 receptor, whereas the IL-1 receptor on pre-B cells, macrophages, and bone marrow cells represents a different gene product. | lld:pubmed |
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| pubmed-article:2530579 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2530579 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2530579 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2530579 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2530579 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:KilianP LPL | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:GublerUU | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:SternA SAS | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:EhmsHH | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:NunesPP | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:ChizzoniteRR | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:KaffkaK LKL | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:TruittTT | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:ParkerK PKP | lld:pubmed |
| pubmed-article:2530579 | pubmed:author | pubmed-author:LuggD KDK | lld:pubmed |
| pubmed-article:2530579 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2530579 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2530579 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2530579 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2530579 | pubmed:pagination | 8029-33 | lld:pubmed |
| pubmed-article:2530579 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2530579 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2530579 | pubmed:articleTitle | Two high-affinity interleukin 1 receptors represent separate gene products. | lld:pubmed |
| pubmed-article:2530579 | pubmed:affiliation | Department of Molecular Genetics, Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110. | lld:pubmed |
| pubmed-article:2530579 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2530579 | pubmed:publicationType | Comparative Study | lld:pubmed |
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