| pubmed-article:2526177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:2526177 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2526177 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2526177 | pubmed:dateCreated | 1989-8-18 | lld:pubmed |
| pubmed-article:2526177 | pubmed:abstractText | Recent reports have indicated that in addition to its well characterized effects on B cells and hepatocytes. IL-6 also affects murine and human T cells and thymocytes. Our study was designed to analyze the effects of IL-1 and IL-6 in providing a second signal in T cell activation in the D10.G4.1 assay. Highly purified human rIL-6 was tested. rIL-6 had modest but detectable activity in the D10.G4.1 assay. Maximal enhancement of proliferation induced by IL-6 in the presence of mitogen in the D10.G4.1 assay was always far less than that induced by IL-1. The D10.G4.1 assay was used to test the possibility of synergistic interactions between IL-1 and IL-6. Quantities of IL-6 which alone were not costimulatory to D10 cells enhanced IL-1-induced D10 proliferation significantly when Con A was used as a costimulus. This synergistic response could be partially blocked by antibodies to rIL-6 and fully blocked by a mAb to rIL-1 alpha. In contrast, when 3D3 (a clonotypic activating anti-TCR mAb) was used as a costimulus, no synergistic interaction between IL-1 and IL-6 could be detected. The proliferation of D10 cells induced by IL-1 and 3D3 was unaffected by antibodies to IL-6 but was completely neutralized by antibodies to IL-1. These data suggest that although IL-6 alone cannot substitute for IL-1 in functional assays for IL-1, the presence of IL-6 significantly enhances T cell responses to IL-1 in the context of the appropriate costimulatory signal. These observations have important implications regarding the specificity and utility of the D10.G4.1 assay for the measurement of IL-1 in biologic samples. | lld:pubmed |
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| pubmed-article:2526177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2526177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2526177 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2526177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2526177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2526177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2526177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2526177 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2526177 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2526177 | pubmed:author | pubmed-author:MizutaniHH | lld:pubmed |
| pubmed-article:2526177 | pubmed:author | pubmed-author:SehgalP BPB | lld:pubmed |
| pubmed-article:2526177 | pubmed:author | pubmed-author:LeuM LML | lld:pubmed |
| pubmed-article:2526177 | pubmed:author | pubmed-author:KupperT STS | lld:pubmed |
| pubmed-article:2526177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2526177 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2526177 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:2526177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2526177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2526177 | pubmed:pagination | 896-901 | lld:pubmed |
| pubmed-article:2526177 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2526177 | pubmed:meshHeading | pubmed-meshheading:2526177-... | lld:pubmed |
| pubmed-article:2526177 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2526177 | pubmed:articleTitle | Synergistic interactions of IL-1 and IL-6 in T cell activation. Mitogen but not antigen receptor-induced proliferation of a cloned T helper cell line is enhanced by exogenous IL-6. | lld:pubmed |
| pubmed-article:2526177 | pubmed:affiliation | Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520. | lld:pubmed |
| pubmed-article:2526177 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2526177 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2526177 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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