Linked Life Data

2492204

Source:http://linkedlifedata.com/resource/pubmed/id/2492204

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:2492204rdf:typepubmed:Citationlld:pubmed
pubmed-article:2492204lifeskim:mentionsumls-concept:C0597032lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0596901lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0597357lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0431085lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0007577lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0003695lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0023749lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0023837lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C1514468lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C2587213lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C1706937lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:2492204lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:2492204pubmed:issue4lld:pubmed
pubmed-article:2492204pubmed:dateCreated1989-3-7lld:pubmed
pubmed-article:2492204pubmed:abstractTextLewis lung carcinoma cells express a plasma membrane receptor (i.e., IRGpIIb/IIIa) which is immunologically and functionally related to the platelet aggregation receptor complex (i.e., GpIIb/IIIa). Both fluorescence microscopy and flow cytometric analysis reveal that surface expression and/or activation of this tumor cell receptor is enhanced by a phorbol ester [i.e., 12-O-tetradecanoylphorbol-13-acetate (TPA)] and a lipoxygenase metabolite of arachidonic acid; 12-hydroxyeicosatetraenoic acid (i.e., 12-HETE). TPA-enhanced expression appears to be mediated by a lipoxygenase metabolite, as this effect can be reversed by lipoxygenase inhibitors but not by cyclooxygenase inhibitors. In parallel with these results both TPA and 12(S)-HETE [but not 12(R)-HETE] enhance tumor cell adhesion to endothelial cells, subendothelial matrix and fibronectin, but not to type IV collagen. TPA-enhanced adhesion can be reduced by lipoxygenase inhibitors but not by cyclooxygenase inhibitors and in addition, stimulated adhesion can be blocked by pretreatment of tumor cells with specific polyclonal or monoclonal antibodies which react against IRGpIIb/IIIa. 12(S)-HETE-enhanced adhesion can also be inhibited by these same antibodies. In contrast, a lipoxygenase product of linoleic acid, 13(S)-hydroxyoctadecadienoic acid, inhibited TPA and 12(S)-HETE-enhanced tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin. These results suggest that (a) IRGpIIb/IIIa is a multifunctional receptor which mediates tumor cell adhesion to a variety of biological substrata, (b) TPA enhances surface expression and/or activation of this receptor possibly via a lipoxygenase metabolite of arachidonic acid, and (c) these effects are opposed by a lipoxygenase metabolite of linoleic acid.lld:pubmed
pubmed-article:2492204pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:languageenglld:pubmed
pubmed-article:2492204pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:citationSubsetIMlld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2492204pubmed:statusMEDLINElld:pubmed
pubmed-article:2492204pubmed:monthFeblld:pubmed
pubmed-article:2492204pubmed:issn0008-5472lld:pubmed
pubmed-article:2492204pubmed:authorpubmed-author:FitzgeraldL...lld:pubmed
pubmed-article:2492204pubmed:authorpubmed-author:DiglioC ACAlld:pubmed
pubmed-article:2492204pubmed:authorpubmed-author:TaylorJ DJDlld:pubmed
pubmed-article:2492204pubmed:authorpubmed-author:HonnK VKVlld:pubmed
pubmed-article:2492204pubmed:authorpubmed-author:NelsonK KKKlld:pubmed
pubmed-article:2492204pubmed:authorpubmed-author:GrossiI MIMlld:pubmed
pubmed-article:2492204pubmed:authorpubmed-author:UmbargerL ALAlld:pubmed
pubmed-article:2492204pubmed:issnTypePrintlld:pubmed
pubmed-article:2492204pubmed:day15lld:pubmed
pubmed-article:2492204pubmed:volume49lld:pubmed
pubmed-article:2492204pubmed:ownerNLMlld:pubmed
pubmed-article:2492204pubmed:authorsCompleteYlld:pubmed
pubmed-article:2492204pubmed:pagination1029-37lld:pubmed
pubmed-article:2492204pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:meshHeadingpubmed-meshheading:2492204-...lld:pubmed
pubmed-article:2492204pubmed:year1989lld:pubmed
pubmed-article:2492204pubmed:articleTitleBidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid.lld:pubmed
pubmed-article:2492204pubmed:affiliationDepartment of Radiation Oncology, Wayne State University, Detroit, Michigan 48202.lld:pubmed
pubmed-article:2492204pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2492204pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:2492204pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2492204lld:pubmed