Linked Life Data

2478401

Source:http://linkedlifedata.com/resource/pubmed/id/2478401

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pubmed-article:2478401pubmed:abstractTextSimian Virus 40 (SV40) transformation of primary cultures of human mammary epithelial cells has yielded a cloned epithelial-like cell line and a representative, single-cell subclone. Although apparently homogeneous, both cloned cell lines can also yield small numbers of three other cell types. The more-elongated cell type can be obtained directly by replating cells from the medium of the epithelial-like cell cultures or by picking and culturing single cells to form representative lines. Immunofluorescent and immunocytochemical analysis of these cell lines growing on plastic or as tumor-nodules in nude mice for epithelial membrane antigens, various cytokeratins, various actins, laminin, Type IV collagen, the common acute lymphoblastic leukemia antigen (CALLA), and a 135-kDa glycoprotein confirm the epithelial nature of the epithelial-like cells and suggest a myoepithelial origin for the more-elongated cell type. Ultrastructural analysis largely confirms the results, although the myofilamental bundles can be scanty in the growing myoepithelial-like cells. The other two cell types are possibly related to the keratinizing and casein-secreting cells seen in the epithelial tumor-nodules before and after mating the mice, respectively. The myoepithelial-like cells produce 5- to 17-fold more laminin, Type IV collagen, CALLA, and the 135-kDa glycoprotein than the epithelial cells, and all of these antigens are preferentially found on myoepithelial cells in vivo. It is suggested that the SV40-transformed epithelial cell is an immortalized form of human mammary stem cell which can differentiate in culture and in vivo to myoepithelial-like cells.lld:pubmed
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pubmed-article:2478401pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:2478401pubmed:articleTitleIsolation of simian virus 40-transformed human mammary epithelial stem cell lines that can differentiate to myoepithelial-like cells in culture and in vivo.lld:pubmed
pubmed-article:2478401pubmed:affiliationBiochemistry Department, University of Liverpool, England.lld:pubmed
pubmed-article:2478401pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2478401pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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