| pubmed-article:2470346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:2470346 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2470346 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2470346 | pubmed:dateCreated | 1989-6-15 | lld:pubmed |
| pubmed-article:2470346 | pubmed:abstractText | Rat islets were used to compare the mechanisms whereby adenosine and adrenaline inhibit insulin release. Adenosine (1 microM-2.5 mM) and its analogue N6(-)-phenylisopropyladenosine (L-PIA) (1 nM-10 microM) caused a concentration-dependent but incomplete (45-60%) inhibition of glucose-stimulated release. L-PIA was more potent than D-PIA [the N6(+) analogue], but much less than adrenaline, which caused nearly complete inhibition (85% at 0.1 microM). 8-Phenyltheophylline prevented the inhibitory effect of L-PIA and 50 microM-adenosine, but not that of 500 microM-adenosine or of adrenaline. In contrast, yohimbine selectively prevented the inhibition by adrenaline. Adenosine and L-PIA thus appear to exert their effects by activating membrane A1 receptors, whereas adrenaline acts on alpha 2-adrenergic receptors. Adenosine, L-PIA and adrenaline slightly inhibited 45Ca2+ efflux, 86Rb+ efflux and 45Ca2+ influx in glucose-stimulated islets. The inhibition of insulin release by adenosine or L-PIA was totally prevented by dibutyryl cyclic AMP, but was only attenuated when adenylate cyclase was activated by forskolin or when protein kinase C was stimulated by a phorbol ester. Adrenaline, on the other hand, inhibited release under these conditions. It is concluded that inhibition of adenylate cyclase, rather than direct changes in membrane K+ and Ca2+ permeabilities, underlies the inhibition of insulin release induced by activation of A1-receptors. The more complete inhibition mediated by alpha 2-adrenergic receptors appears to result from a second mechanism not triggered by adenosine. | lld:pubmed |
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| pubmed-article:2470346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2470346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2470346 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2470346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2470346 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2470346 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2470346 | pubmed:author | pubmed-author:BertrandGG | lld:pubmed |
| pubmed-article:2470346 | pubmed:author | pubmed-author:HenquinJ CJC | lld:pubmed |
| pubmed-article:2470346 | pubmed:author | pubmed-author:NenquinMM | lld:pubmed |
| pubmed-article:2470346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2470346 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2470346 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:2470346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2470346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2470346 | pubmed:pagination | 223-8 | lld:pubmed |
| pubmed-article:2470346 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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