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pubmed-article:2468324pubmed:abstractTextProduction of human chorionic gonadotropin by sarcomas is an uncommon phenomenon that has rarely been documented. A case of a 26-year-old woman with osteosarcoma of the left fibula and high levels of serum beta-human chorionic gonadotropin (beta-HCG) is described. Immunoperoxidase staining showed numerous tumor cells reacting with the beta-HCG antibody. Immunohistochemical studies performed on ten additional osteosarcomas demonstrated another case in which some tumor cells presented immunoreactivity for beta-HCG. These results indicate that beta-HCG may be used as a marker of persistent or recurrent disease in those uncommon cases of osteosarcoma in which serum levels of beta-HCG are elevated at the onset of treatment.lld:pubmed
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pubmed-article:2468324pubmed:authorpubmed-author:OrdóñezN GNGlld:pubmed
pubmed-article:2468324pubmed:authorpubmed-author:AyalaA GAGlld:pubmed
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pubmed-article:2468324pubmed:authorpubmed-author:RaymondA KAKlld:pubmed
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pubmed-article:2468324pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2468324pubmed:articleTitleEctopic production of the beta-subunit of human chorionic gonadotropin in osteosarcoma.lld:pubmed
pubmed-article:2468324pubmed:affiliationDepartment of Pathology, University of Texas M. D. Anderson Hospital, Houston 77030.lld:pubmed
pubmed-article:2468324pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2468324pubmed:publicationTypeCase Reportslld:pubmed
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