| pubmed-article:2466519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2466519 | lifeskim:mentions | umls-concept:C0018792 | lld:lifeskim |
| pubmed-article:2466519 | lifeskim:mentions | umls-concept:C0001471 | lld:lifeskim |
| pubmed-article:2466519 | lifeskim:mentions | umls-concept:C0028127 | lld:lifeskim |
| pubmed-article:2466519 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2466519 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2466519 | lifeskim:mentions | umls-concept:C0682770 | lld:lifeskim |
| pubmed-article:2466519 | lifeskim:mentions | umls-concept:C0004855 | lld:lifeskim |
| pubmed-article:2466519 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2466519 | pubmed:dateCreated | 1989-5-5 | lld:pubmed |
| pubmed-article:2466519 | pubmed:abstractText | 1. (-)-N6-phenylisopropyladenosine (R-PIA) and N6-cyclohexyladenosine (CHA), highly selective agonists at A1-adenosine receptors, 5'-N-ethyl-carboxamidoadenosine (NECA), a non-selective agonist at A1 and A2 receptors, and 2-phenylaminoadenosine (CV-1808), a selective A2 agonist, were compared in spontaneously beating and electrically driven atria. R-PIA, CHA and NECA inhibited contraction in both preparations. CV-1808 was not effective up to 500 nM. 2. 1,3-Dipropyl-8-cyclopentylxanthine (DPCPX), a new selective A1 receptor antagonist, competitively inhibited the effects of the adenosine agonists, at low concentrations (IC50 less than 1 nM). 3. CHA and NECA were able to inhibit the positive inotropic effect of Bay K 8644 both in spontaneously beating and in electrically driven atria. 4. R-PIA, CHA and NECA (agonists), 8-phenyltheophylline (PT) and DPCPX (antagonists), failed to influence [3H]-nitrendipine binding on microsomal membranes from guinea-pig atria and ventricles in a range of concentrations from 1 nM to 100 microM. 5. The data support the existence of A1 receptors in atrial tissue. No evidence for a direct interaction between adenosine analogues and Bay K 8644 was found at the level of slow calcium channels. Adenosine analogues appear to antagonize the effects of Bay K 8644 indirectly by activation of A1 receptors. | lld:pubmed |
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| pubmed-article:2466519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2466519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2466519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2466519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2466519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2466519 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2466519 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:2466519 | pubmed:author | pubmed-author:PandolfoLL | lld:pubmed |
| pubmed-article:2466519 | pubmed:author | pubmed-author:FassinaGG | lld:pubmed |
| pubmed-article:2466519 | pubmed:author | pubmed-author:CaparrottaLL | lld:pubmed |
| pubmed-article:2466519 | pubmed:author | pubmed-author:BoreaP APA | lld:pubmed |
| pubmed-article:2466519 | pubmed:author | pubmed-author:RagazziEE | lld:pubmed |
| pubmed-article:2466519 | pubmed:author | pubmed-author:FroldiGG | lld:pubmed |
| pubmed-article:2466519 | pubmed:author | pubmed-author:De BiasiMM | lld:pubmed |
| pubmed-article:2466519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2466519 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:2466519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2466519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2466519 | pubmed:pagination | 372-8 | lld:pubmed |
| pubmed-article:2466519 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2466519 | pubmed:meshHeading | pubmed-meshheading:2466519-... | lld:pubmed |
| pubmed-article:2466519 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2466519 | pubmed:articleTitle | Effect of selective agonists and antagonists on atrial adenosine receptors and their interaction with Bay K 8644 and [3H]-nitrendipine. | lld:pubmed |
| pubmed-article:2466519 | pubmed:affiliation | Department of Pharmacology, Padua University, Italy. | lld:pubmed |
| pubmed-article:2466519 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2466519 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2466519 | pubmed:publicationType | In Vitro | lld:pubmed |
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