| pubmed-article:2463968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0036111 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0020843 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2463968 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2463968 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2463968 | pubmed:dateCreated | 1989-3-1 | lld:pubmed |
| pubmed-article:2463968 | pubmed:abstractText | Using a modification of the splenic focus assay, we analyzed the Salmonella typhimurium-specific B-cell repertoire in salmonella-susceptible BALB/c mice. Although these mice normally succumbed to salmonella infection before antibody was produced, they appeared to have splenic S. typhimurium-specific B-cell precursors that could be activated to differentiate and secrete antibody in a manner which was quantitatively and qualitatively identical to that of salmonella-resistant mouse strains. We also analyzed the primary S. typhimurium-specific B-cell repertoire in BALB/c mice that had been chronically treated with antibodies to immunoglobulin D (IgD) and therefore had no surface IgD-positive B cells. Although the frequency of S. typhimurium-specific precursors in these mice was similar to that of control mice, there was an apparent alteration in the isotype distribution pattern in anti-IgD-treated mice. Control mice generated a significantly greater proportion of IgG-secreting clones than did anti-IgD-treated mice. In addition, a greater proportion of S. typhimurium-specific clones from control mice secreted IgG2 than secreted IgG1, and those clones that secreted IgG2 but not IgM, IgG3, or IgG1 were greater than 20-fold more common in control than in anti-IgD-treated mice. Finally, we analyzed the immune response of control and anti-IgD-treated mice to a live avirulent vaccine, S. typhimurium SL3235. Although both groups were protected after challenge with a live virulent S. typhimurium strain, only the control mice made serum antibodies to this vaccine. Taken together, these results show that (i) salmonella-susceptible BALB/c mice have S. typhimurium-specific B cells, (ii) the S. typhimurium-specific B cells in anti-IgD-treated mice may have a restricted capacity to switch heavy-chain classes, (iii) the similarity observed in the frequency of the S. typhimurium-specific precursors for these two groups of BALB/c mice is not reflected in the serum, and (iv) the failure of anti-IgD-treated mice to generate a serum antibody response to SL3235 in the face of complete protection suggests that this model may be used to study cell-mediated immune mechanisms in the apparent absence of humoral immunity. | lld:pubmed |
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| pubmed-article:2463968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2463968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2463968 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2463968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2463968 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2463968 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:2463968 | pubmed:author | pubmed-author:MetcalfE SES | lld:pubmed |
| pubmed-article:2463968 | pubmed:author | pubmed-author:FinkelmanF... | lld:pubmed |
| pubmed-article:2463968 | pubmed:author | pubmed-author:FultzM JMJ | lld:pubmed |
| pubmed-article:2463968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2463968 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:2463968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2463968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2463968 | pubmed:pagination | 432-7 | lld:pubmed |
| pubmed-article:2463968 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2463968 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2463968 | pubmed:articleTitle | Altered expression of the Salmonella typhimurium-specific B-cell repertoire in mice chronically treated with antibodies to immunoglobulin D. | lld:pubmed |
| pubmed-article:2463968 | pubmed:affiliation | Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. | lld:pubmed |
| pubmed-article:2463968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2463968 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2463968 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2463968 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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