| pubmed-article:2455461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2455461 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:2455461 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:2455461 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:2455461 | lifeskim:mentions | umls-concept:C0243046 | lld:lifeskim |
| pubmed-article:2455461 | lifeskim:mentions | umls-concept:C0018249 | lld:lifeskim |
| pubmed-article:2455461 | lifeskim:mentions | umls-concept:C1262479 | lld:lifeskim |
| pubmed-article:2455461 | lifeskim:mentions | umls-concept:C1831759 | lld:lifeskim |
| pubmed-article:2455461 | pubmed:dateCreated | 1988-8-4 | lld:pubmed |
| pubmed-article:2455461 | pubmed:abstractText | Compounds that produce depolarization of nociceptive neurons in the dorsal horn of the spinal cord also elicit a rather specific kind of caudally directed biting, licking, and/or scratching behavior when they are injected intrathecally in mice. We sought to use this elicited grooming behavior as a test for compounds that might inhibit the neurons excited by the excitatory agents. All three neurokinins--substance P, neurokinin A (substance K), neurokinin B (neuromedin K)--and excitatory amino acids active at N-methyl-D-aspartate (NMDA) or quisqualate receptors produce similar behaviors, which last for 1 minute after i.t. injection. Our data indicate that mu opioid agonists or alpha adrenergic agonists block both neurokinin-elicited behavior and EAA-elicited behavior; delta opioid agonists block only neurokinin-elicited behavior; and PCP/sigma "opioid" agonists block only EAA-elicited behavior. Somatostatin and serotonin produce qualitatively different behaviors by themselves and, when administered with neurokinins, partially block neurokinin-elicited behavior. | lld:pubmed |
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| pubmed-article:2455461 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2455461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2455461 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:2455461 | pubmed:author | pubmed-author:WilcoxG LGL | lld:pubmed |
| pubmed-article:2455461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2455461 | pubmed:volume | 525 | lld:pubmed |
| pubmed-article:2455461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2455461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2455461 | pubmed:pagination | 228-36 | lld:pubmed |
| pubmed-article:2455461 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2455461 | pubmed:meshHeading | pubmed-meshheading:2455461-... | lld:pubmed |
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| pubmed-article:2455461 | pubmed:meshHeading | pubmed-meshheading:2455461-... | lld:pubmed |
| pubmed-article:2455461 | pubmed:meshHeading | pubmed-meshheading:2455461-... | lld:pubmed |
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| pubmed-article:2455461 | pubmed:meshHeading | pubmed-meshheading:2455461-... | lld:pubmed |
| pubmed-article:2455461 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2455461 | pubmed:articleTitle | Pharmacological studies of grooming and scratching behavior elicited by spinal substance P and excitatory amino acids. | lld:pubmed |
| pubmed-article:2455461 | pubmed:affiliation | Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455. | lld:pubmed |
| pubmed-article:2455461 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2455461 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2455461 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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