| pubmed-article:2443458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2443458 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2443458 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:2443458 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2443458 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2443458 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:2443458 | lifeskim:mentions | umls-concept:C1383092 | lld:lifeskim |
| pubmed-article:2443458 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2443458 | pubmed:dateCreated | 1987-11-20 | lld:pubmed |
| pubmed-article:2443458 | pubmed:abstractText | In this study we investigated the modulation of natural killer (NK) cell activity by various histamine receptor antagonists in vitro. The histamine H2-receptor antagonists cimetidine, ranitidine and tiotidine suppressed NK cell cytotoxicity (NKCC) at a high concentration (10(-3) M). Cimetidine enhanced NKCC of Ficoll-Hypaque-separated lymphocytes and of lymphocytes enriched for NKCC by Percoll density gradient centrifugation. The enhancing effect of cimetidine was dose-dependent at final concentrations of 10(-4)-10(-7) M and did not require the presence of adherent cells/monocytes. Ranitidine did not affect NKCC over a wide range of concentrations. Tiotidine strongly enhanced NKCC of low-density, large granular lymphocyte-enriched mononuclear cells (MNC) in the presence of adherent cells/monocytes, but was ineffective in nonadherent effector cells. All H2-receptor antagonists clearly antagonized histamine-induced NKCC enhancement in monocyte-containing effector cells. Clemastin, a specific H1-receptor antagonist, effectively suppressed NKCC. This effect was mimicked by a clemastin isomer with very low affinity for H1-receptors. We conclude that (1) cimetidine enhances NKCC in vitro by a mechanism of action that is not specifically related to antagonism of H2-receptors, (2) tiotidine displays mixed agonist/antagonist properties for MNC H2-receptors and (3) NK-suppressive properties of clemastin are unrelated to H1-receptor antagonism. | lld:pubmed |
| pubmed-article:2443458 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2443458 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443458 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2443458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2443458 | pubmed:issn | 0020-5915 | lld:pubmed |
| pubmed-article:2443458 | pubmed:author | pubmed-author:HermodssonSS | lld:pubmed |
| pubmed-article:2443458 | pubmed:author | pubmed-author:HellstrandKK | lld:pubmed |
| pubmed-article:2443458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2443458 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:2443458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2443458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2443458 | pubmed:pagination | 247-55 | lld:pubmed |
| pubmed-article:2443458 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:meshHeading | pubmed-meshheading:2443458-... | lld:pubmed |
| pubmed-article:2443458 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2443458 | pubmed:articleTitle | Differential effects of histamine receptor antagonists on human natural killer cell activity. | lld:pubmed |
| pubmed-article:2443458 | pubmed:affiliation | Department of Virology, University of Göteborg, Sweden. | lld:pubmed |
| pubmed-article:2443458 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2443458 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2443458 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2443458 | lld:pubmed |
