| pubmed-article:2432227 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C0038869 | lld:lifeskim |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C0439590 | lld:lifeskim |
| pubmed-article:2432227 | lifeskim:mentions | umls-concept:C2826347 | lld:lifeskim |
| pubmed-article:2432227 | pubmed:dateCreated | 1987-2-3 | lld:pubmed |
| pubmed-article:2432227 | pubmed:abstractText | The occurrence and ionic basis of prolonged plateau depolarizations were studied during intracellular recordings obtained from thirty-nine supraoptic nucleus (s.o.n.) neurosecretory neurones in perfused explants of rat hypothalamus. Replacement of Ca2+ by Ba2+ in the perfusion media enhanced the shoulder on the repolarization phase of the action potentials in all of eleven cells tested. In Ba2+, spike durations increased as the holding membrane potential was made more positive, resulting in plateaux lasting up to 100 s. These plateaux were characterized by a sustained but slowly decaying absolute potential near 0 mV from which there appeared frequent spontaneous hyperpolarizing transients. A membrane resistance decrease of more than 50% was observed at the onset of a plateau, with gradual restoration during the plateau. Injection of Cs+ into twenty-one cells abolished the spike frequency adaptation and after-hyperpolarization associated with current-evoked bursts of action potentials. Mean spike duration after Cs+ injection increased from 2.5 +/- 0.3 ms to 68 +/- 9 ms (S.E. of mean). Addition of 4-5 mM-tetraethylammonium (TEA) to the perfusion media further increased the spike duration of nine Cs+-injected cells to 320 +/- 70 ms. No further increase could be obtained by doubling the concentration of TEA and/or by the addition of 0.2-0.5 mM-4-aminopyridine to the media. Although spike duration was greatly prolonged during such extensive blockade of K+ channels, plateau potentials lasting for longer than 1 s were observed only when Ba2+ was eventually added to the perfusion media. The special property of Ba2+ that leads to the formation of plateau potentials in s.o.n. neurones is therefore not restricted to its ability to reduce K+ conductances but may reside in its reduced effectiveness as a mediator of Ca2+-dependent inactivation of Ca2+ channels. Injection of Cs+ into s.o.n. neurones increased the slope of their current-voltage relationship below -60 mV from 148 +/- 15 to 257 +/- 41 M omega (S.E. of mean) and eliminated the outward rectification present at potentials above -60 mV. K+ currents are presumably active near the resting potential of these cells. Addition of Ba2+ to the perfusion media revealed a Cd2+-sensitive inward rectification above but not below ca. -55 mV. A slowly inactivating Ba2+ current is therefore carried through Ca2+ channels at potentials above -55 mV.(ABSTRACT TRUNCATED AT 400 WORDS) | lld:pubmed |
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| pubmed-article:2432227 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2432227 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2432227 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2432227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2432227 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2432227 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2432227 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:2432227 | pubmed:author | pubmed-author:RenaudL PLP | lld:pubmed |
| pubmed-article:2432227 | pubmed:author | pubmed-author:CRAIGA BAB | lld:pubmed |
| pubmed-article:2432227 | pubmed:author | pubmed-author:BourqueC WCW | lld:pubmed |
| pubmed-article:2432227 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2432227 | pubmed:volume | 375 | lld:pubmed |
| pubmed-article:2432227 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2432227 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2432227 | pubmed:pagination | 573-86 | lld:pubmed |
| pubmed-article:2432227 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2432227 | pubmed:meshHeading | pubmed-meshheading:2432227-... | lld:pubmed |
| pubmed-article:2432227 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2432227 | pubmed:articleTitle | Barium ions induce prolonged plateau depolarizations in neurosecretory neurones of the adult rat supraoptic nucleus. | lld:pubmed |
| pubmed-article:2432227 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2432227 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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