| pubmed-article:2420478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2420478 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2420478 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2420478 | lifeskim:mentions | umls-concept:C0035298 | lld:lifeskim |
| pubmed-article:2420478 | lifeskim:mentions | umls-concept:C0070798 | lld:lifeskim |
| pubmed-article:2420478 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:2420478 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2420478 | pubmed:dateCreated | 1986-5-9 | lld:pubmed |
| pubmed-article:2420478 | pubmed:abstractText | Light-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate (TPI) to 1,2-diacylglycerol and D-myo-inositol 1,4,5-triphosphate (IP3) has been reported in the visual photoreceptor cells. We have investigated the localization of the TPI antigenic sites in dark- and light-adapted rat retinas using rabbit anti TPI antibodies (Ab). Sprague-Dawley rats were dark-, or light-adapted, or were exposed to a light flash. The eyes were fixed immediately and the tissue sections stained with the rabbit anti TPI Ab. The peroxidase-antiperoxidase method was used to find the localization of the TPI antigenic site. Image analysis of the sections was performed to obtain optical density profiles of the stain. Dark-adapted retinas showed intense staining of the rod outer segment (OS) layer but much less staining of the rod inner segment layer. Compared with the OS of dark-adapted retinas, those of the flash-bleached retinas were stained much less. The OS of fully bleached retinas showed little or no staining. The anti TPI Ab-protein A-gold conjugate intensely stained disks from dark-adapted retina but those from bleached retina much less. Our results suggest that rapid hydrolysis of TPI in rat rod outer segments occurs in vivo in response to light. | lld:pubmed |
| pubmed-article:2420478 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2420478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2420478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2420478 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2420478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2420478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2420478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2420478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2420478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2420478 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2420478 | pubmed:issn | 0386-7196 | lld:pubmed |
| pubmed-article:2420478 | pubmed:author | pubmed-author:ShichiHH | lld:pubmed |
| pubmed-article:2420478 | pubmed:author | pubmed-author:DasN DND | lld:pubmed |
| pubmed-article:2420478 | pubmed:author | pubmed-author:YoshiokaTT | lld:pubmed |
| pubmed-article:2420478 | pubmed:author | pubmed-author:SamuelsonDD | lld:pubmed |
| pubmed-article:2420478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2420478 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:2420478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2420478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2420478 | pubmed:pagination | 53-63 | lld:pubmed |
| pubmed-article:2420478 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
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| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
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| pubmed-article:2420478 | pubmed:meshHeading | pubmed-meshheading:2420478-... | lld:pubmed |
| pubmed-article:2420478 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2420478 | pubmed:articleTitle | Immunocytochemical localization of phosphatidylinositol-4,5-bisphosphate in dark- and light-adapted rat retinas. | lld:pubmed |
| pubmed-article:2420478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2420478 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2420478 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2420478 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2420478 | lld:pubmed |
