| pubmed-article:2411738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2411738 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:2411738 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:2411738 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:2411738 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2411738 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2411738 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2411738 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2411738 | pubmed:dateCreated | 1985-10-9 | lld:pubmed |
| pubmed-article:2411738 | pubmed:abstractText | We have previously characterized a monoclonal antibody, S12, that binds only to activated platelets (McEver, R.P., and M.N. Martin, 1984, J. Biol. Chem., 259:9799-9804). It identifies a platelet membrane protein of Mr 140,000, which we have designated as GMP-140. Using immunocytochemical techniques we have now localized this protein in unstimulated and thrombin-stimulated platelets. Polyclonal antibodies to purified GMP-140 were used to enhance the sensitivity of detection. Nonpermeabilized, unstimulated platelets, incubated with anti-GMP-140 antibodies, and then with IgG-gold probes, showed very little label for GMP-140 along their plasma membranes. In contrast, thrombin-stimulated platelets exhibited at least a 50-fold increase in the amount of label along the plasma membrane. On frozen thin sections of unstimulated platelets we observed immunogold label along the alpha-granule membranes. We also employed the more sensitive technique of permeabilizing with saponin unstimulated platelets in suspension, and then incubating the cells with polyclonal anti-GMP-140 antibodies and Fab-peroxidase conjugate. Alpha-granule membranes showed heavy reaction product, but no other intracellular organelles were specifically labeled. These results demonstrate that GMP-140 is an alpha-granule membrane protein that is expressed on the platelet plasma membrane during degranulation. | lld:pubmed |
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| pubmed-article:2411738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2411738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2411738 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2411738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2411738 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2411738 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:2411738 | pubmed:author | pubmed-author:BaintonD FDF | lld:pubmed |
| pubmed-article:2411738 | pubmed:author | pubmed-author:JacquesY VYV | lld:pubmed |
| pubmed-article:2411738 | pubmed:author | pubmed-author:ShumanM AMA | lld:pubmed |
| pubmed-article:2411738 | pubmed:author | pubmed-author:StenbergP EPE | lld:pubmed |
| pubmed-article:2411738 | pubmed:author | pubmed-author:McEverR PRP | lld:pubmed |
| pubmed-article:2411738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2411738 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:2411738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2411738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2411738 | pubmed:pagination | 880-6 | lld:pubmed |
| pubmed-article:2411738 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2411738 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2411738 | pubmed:articleTitle | A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. | lld:pubmed |
| pubmed-article:2411738 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2411738 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2411738 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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