| pubmed-article:2410443 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0019932 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0001206 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:2410443 | lifeskim:mentions | umls-concept:C0815016 | lld:lifeskim |
| pubmed-article:2410443 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2410443 | pubmed:dateCreated | 1985-9-16 | lld:pubmed |
| pubmed-article:2410443 | pubmed:abstractText | Basal serum concentrations of glycoprotein hormone alpha-subunit and its response to GH-releasing hormone (GHRH) were studied in 22 acromegalic patients and in normal subjects. Four out of 22 patients had a basal alpha-subunit concentration (1.2-3.5 ng/ml) clearly above the upper limit of the normal range. GHRH injection (1 microgram/kg body weight, bolus dose iv) produced a clear alpha-subunit response [mean % increase: 120 +/- 37 (SD)] in the 4 patients with elevated basal alpha-subunit levels. No increase in serum glycoprotein hormones (TSH, LH, and FSH) occurred. Selective adenomectomy in 2 patients resulted in normalization of both serum GH and alpha-subunit levels, as well as disappearance of the abnormal alpha-subunit response to GHRH. In in vitro studies, only these 2 adenomas secreted alpha-subunit in large amounts (534 and 388 ng/mg protein . 30 min) and was it further stimulated by GHRH (% increase: 83 and 126). Morphological studies done with protein A-gold particle immunotechnique demonstrated that in these adenomas the great majority of the cells contained secretory granules positive for both GH and alpha-subunit. We conclude that: 1) alpha-subunit hypersecretion is present in some acromegalic patients (about 20%), 2) GHRH stimulates alpha-subunit release both in vivo and in vitro only in patients with elevated basal alpha-subunit levels, and 3) in these patients alpha-subunit derives from a common adenomatous cell secreting both alpha-subunit and GH molecules. | lld:pubmed |
| pubmed-article:2410443 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2410443 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2410443 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2410443 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2410443 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:2410443 | pubmed:author | pubmed-author:FagliaGG | lld:pubmed |
| pubmed-article:2410443 | pubmed:author | pubmed-author:SpadaAA | lld:pubmed |
| pubmed-article:2410443 | pubmed:author | pubmed-author:Beck-PeccozPP | lld:pubmed |
| pubmed-article:2410443 | pubmed:author | pubmed-author:GiannattasioG... | lld:pubmed |
| pubmed-article:2410443 | pubmed:author | pubmed-author:ArosioMM | lld:pubmed |
| pubmed-article:2410443 | pubmed:author | pubmed-author:BassettiMM | lld:pubmed |
| pubmed-article:2410443 | pubmed:author | pubmed-author:MedriGG | lld:pubmed |
| pubmed-article:2410443 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2410443 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:2410443 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2410443 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2410443 | pubmed:pagination | 541-6 | lld:pubmed |
| pubmed-article:2410443 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:meshHeading | pubmed-meshheading:2410443-... | lld:pubmed |
| pubmed-article:2410443 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2410443 | pubmed:articleTitle | Glycoprotein hormone alpha-subunit response to growth hormone (GH)-releasing hormone in patients with active acromegaly. Evidence for alpha-subunit and GH coexistence in the same tumoral cell. | lld:pubmed |
| pubmed-article:2410443 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2410443 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2410443 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2410443 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2410443 | lld:pubmed |
