| pubmed-article:2409523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2409523 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:2409523 | lifeskim:mentions | umls-concept:C0040549 | lld:lifeskim |
| pubmed-article:2409523 | lifeskim:mentions | umls-concept:C0010284 | lld:lifeskim |
| pubmed-article:2409523 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:2409523 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:2409523 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2409523 | lifeskim:mentions | umls-concept:C0997896 | lld:lifeskim |
| pubmed-article:2409523 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2409523 | pubmed:dateCreated | 1985-8-20 | lld:pubmed |
| pubmed-article:2409523 | pubmed:abstractText | The effects of three toxins (ATX I, II, III) isolated from the sea anemone Anemonia sulcata were studied in the soma membrane of a crustacean neurone under voltage-clamp conditions. All three toxins affected the action potentials and the Na+ currents in a similar manner. The lowest concentrations tested (10 nM, 20 nM and 50 nM for ATX I, II and III, respectively) had pronounced selective effects on the Na+ current. No effect on K+ or Ca2+ currents was observed with concentrations up to 5 microM. In the presence of ATX the Na+ inactivation was incomplete even with pulses of 700 ms length or strong depolarizing prepulses. Besides the effects on the inactivation process ATX affected also the activation of the Na+ current. In cells treated with ATX the negative resistance branch of the peak Na+ current voltage relation was shifted by -5 mV to -20 mV. The time to peak was increased for small depolarizations (up to -30 mV) and the rate of rise (delta I/delta t) was enlarged by ATX. A slow activating current component was also observed after depolarizing prepulses or if the Na+ current was outward. The decay of the Na+ tail currents was considerably prolonged after the application of ATX if the membrane was repolarized to potentials more positive than about -60 mV. Repetitive stimulation led to a shortening of the action potential in ATX II treated neurones. A simultaneous and parallel decrement of the peak and plateau current was observed with depolarizing voltage steps. | lld:pubmed |
| pubmed-article:2409523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2409523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2409523 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2409523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2409523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2409523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2409523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2409523 | pubmed:month | May | lld:pubmed |
| pubmed-article:2409523 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:2409523 | pubmed:author | pubmed-author:RathmayerWW | lld:pubmed |
| pubmed-article:2409523 | pubmed:author | pubmed-author:HartungKK | lld:pubmed |
| pubmed-article:2409523 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2409523 | pubmed:volume | 404 | lld:pubmed |
| pubmed-article:2409523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2409523 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2409523 | pubmed:pagination | 119-25 | lld:pubmed |
| pubmed-article:2409523 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:meshHeading | pubmed-meshheading:2409523-... | lld:pubmed |
| pubmed-article:2409523 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2409523 | pubmed:articleTitle | Anemonia sulcata toxins modify activation and inactivation of Na+ currents in a crayfish neurone. | lld:pubmed |
| pubmed-article:2409523 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2409523 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2409523 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2409523 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2409523 | lld:pubmed |
