| pubmed-article:2406030 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C0017366 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C0040627 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:2406030 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:2406030 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2406030 | pubmed:dateCreated | 1990-3-28 | lld:pubmed |
| pubmed-article:2406030 | pubmed:abstractText | Expression of human immunodeficiency virus type 1 structural proteins requires both the viral Rev trans-activator and its cis-acting RNA target sequence, the Rev response element (RRE). The RRE has been mapped to a conserved region of the HIV-1 env gene and is predicted to form a complex, highly stable RNA stem-loop structure. Site-directed mutagenesis was used to define a small subdomain of the RRE, termed stem-loop II, that is essential for biological activity. Gel retardation assays demonstrated that the Rev trans-activator is a sequence-specific RNA binding protein. The RRE stem-loop II subdomain was found to be both necessary and sufficient for the binding of Rev by the RRE. We propose that the HIV-1 Rev trans-activator belongs to a new class of sequence-specific RNA binding proteins characterized by the presence of an arginine-rich binding motif. | lld:pubmed |
| pubmed-article:2406030 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2406030 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2406030 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2406030 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2406030 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2406030 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2406030 | pubmed:author | pubmed-author:CullenB RBR | lld:pubmed |
| pubmed-article:2406030 | pubmed:author | pubmed-author:TileyL SLS | lld:pubmed |
| pubmed-article:2406030 | pubmed:author | pubmed-author:HauberJJ | lld:pubmed |
| pubmed-article:2406030 | pubmed:author | pubmed-author:MalimM HMH | lld:pubmed |
| pubmed-article:2406030 | pubmed:author | pubmed-author:RuscheJ RJR | lld:pubmed |
| pubmed-article:2406030 | pubmed:author | pubmed-author:McCarnD FDF | lld:pubmed |
| pubmed-article:2406030 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2406030 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:2406030 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:2406030 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2406030 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2406030 | pubmed:pagination | 675-83 | lld:pubmed |
| pubmed-article:2406030 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2406030 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2406030 | pubmed:articleTitle | HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. | lld:pubmed |
| pubmed-article:2406030 | pubmed:affiliation | Howard Hughes Medical Institute, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710. | lld:pubmed |
| pubmed-article:2406030 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2406030 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2406030 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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