| pubmed-article:2358774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0023493 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C1366557 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0039371 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2358774 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2358774 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2358774 | pubmed:dateCreated | 1990-8-1 | lld:pubmed |
| pubmed-article:2358774 | pubmed:abstractText | We examined the effect of the human T lymphotropic virus type 1 (HTLV-I) Tax gene product on the human transforming growth factor beta 1 (TGF-beta 1) promoter. Transfection of deleted constructs of the TGF-beta 1 promoter revealed regions homologous with AP-1 binding sites that were required for Tax-induced transactivation of the TGF-beta 1 promoter. In addition, we examined the expression and secretion of TGF-beta in fresh leukemic cells isolated from patients with adult T cell leukemia (ATL) and in HTLV-1-infected T cell lines. We report that fresh leukemic cells from ATL patients constitutively produce high levels of TGF-beta 1 mRNA and secrete TGF-beta 1 but not TGF-beta 2 into the culture medium. In addition, long-term ATL cell lines expressed significant amounts of TGF-beta 1 mRNA as well as detectable levels of TGF-beta 1 protein. These results suggest a role for Tax in the upregulation of TGF-beta 1 in HTLV-I-infected cells. | lld:pubmed |
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| pubmed-article:2358774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2358774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2358774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2358774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2358774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2358774 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2358774 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:BurtonJJ | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:KimS JSJ | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:SpornM BMB | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:RobertsA BAB | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:KimK YKY | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:DanielpourDD | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:KehrlJ HJH | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:TheveninCC | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:JeangK TKT | lld:pubmed |
| pubmed-article:2358774 | pubmed:author | pubmed-author:TendlerC LCL | lld:pubmed |
| pubmed-article:2358774 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2358774 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2358774 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:2358774 | pubmed:owner | NLM | lld:pubmed |
