| pubmed-article:2356212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2356212 | lifeskim:mentions | umls-concept:C0684336 | lld:lifeskim |
| pubmed-article:2356212 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2356212 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:2356212 | lifeskim:mentions | umls-concept:C0004442 | lld:lifeskim |
| pubmed-article:2356212 | lifeskim:mentions | umls-concept:C0069772 | lld:lifeskim |
| pubmed-article:2356212 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:2356212 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2356212 | pubmed:dateCreated | 1990-7-20 | lld:pubmed |
| pubmed-article:2356212 | pubmed:abstractText | The nicotinic antagonist mecamylamine (2.5 and 5 mg/kg/IP) depressed both active (shuttle-box) and passive (step-through) avoidance learning in mice of the DBA/2 strain. The nootropic drug oxiracetam (50 and 100 mg/kg/IP) improved acquisition in the multitrial active avoidance test, but had no effect on one-trial passive avoidance learning. When the two drugs were combined, oxiracetam did not counteract mecamylamine-induced impairment of passive avoidance learning, even if it maintained a facilitating action on shuttle-box avoidance acquisition in mice receiving the nicotinic receptor blocker. Prevention of mecamylamine-induced shuttle-box avoidance depression by oxiracetam indicates that central nicotinic mechanisms are probably involved in the improving effects exerted by nootropic drugs on learning. | lld:pubmed |
| pubmed-article:2356212 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2356212 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2356212 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2356212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2356212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2356212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2356212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2356212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2356212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2356212 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2356212 | pubmed:issn | 0091-3057 | lld:pubmed |
| pubmed-article:2356212 | pubmed:author | pubmed-author:SansoneMM | lld:pubmed |
| pubmed-article:2356212 | pubmed:author | pubmed-author:CastellanoCC | lld:pubmed |
| pubmed-article:2356212 | pubmed:author | pubmed-author:BattagliaMM | lld:pubmed |
| pubmed-article:2356212 | pubmed:author | pubmed-author:Ammassari-Teu... | lld:pubmed |
| pubmed-article:2356212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2356212 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:2356212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2356212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2356212 | pubmed:pagination | 389-92 | lld:pubmed |
| pubmed-article:2356212 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:meshHeading | pubmed-meshheading:2356212-... | lld:pubmed |
| pubmed-article:2356212 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2356212 | pubmed:articleTitle | Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice. | lld:pubmed |
| pubmed-article:2356212 | pubmed:affiliation | Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy. | lld:pubmed |
| pubmed-article:2356212 | pubmed:publicationType | Journal Article | lld:pubmed |
