| pubmed-article:2353922 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0016452 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C1287349 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C0064074 | lld:lifeskim |
| pubmed-article:2353922 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:2353922 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2353922 | pubmed:dateCreated | 1990-7-16 | lld:pubmed |
| pubmed-article:2353922 | pubmed:abstractText | The influence of food restriction (FR) on the drug-inducible capacity of liver microsomal cytochrome P-450s IA1, IA2 and IIB1 and IIB2 was studied in 20-month-old male Fischer-344 rats. ELISA and Western Blotting revealed that the induction of the cytochrome P-450-IA1/IA2 and P-450-IIB1/IIB2 enzymes was considerably higher in the liver microsomes of FR rats than in their ad libitum (AL) fed counterparts. In order to determine whether the higher P-450 enzyme levels in FR rats were a reflection of an increased synthesis rate or a stabilization of these enzymes, hybridization studies were performed with a cDNA probe for P-450-IIB1/IIB2. These studies show markedly higher levels of P-450-IIB1/IIB2 mRNAs in the livers of FR rats as compared to AL animals. These results suggest that it is possible to prevent the age-dependent loss of drug-induced cytochrome P-450s by 40% dietary restriction which suggest FR may improve the drug-metabolizing capacity during aging. | lld:pubmed |
| pubmed-article:2353922 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2353922 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2353922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2353922 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2353922 | pubmed:issn | 0158-5231 | lld:pubmed |
| pubmed-article:2353922 | pubmed:author | pubmed-author:FernandesGG | lld:pubmed |
| pubmed-article:2353922 | pubmed:author | pubmed-author:HorbachG JGJ | lld:pubmed |
| pubmed-article:2353922 | pubmed:author | pubmed-author:VenkatramanJ... | lld:pubmed |
| pubmed-article:2353922 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2353922 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:2353922 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2353922 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2353922 | pubmed:pagination | 725-30 | lld:pubmed |
| pubmed-article:2353922 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:meshHeading | pubmed-meshheading:2353922-... | lld:pubmed |
| pubmed-article:2353922 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2353922 | pubmed:articleTitle | Food restriction prevents the loss of isosafrole inducible cytochrome P-450 mRNA and enzyme levels in aging rats. | lld:pubmed |
| pubmed-article:2353922 | pubmed:affiliation | Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7874. | lld:pubmed |
| pubmed-article:2353922 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2353922 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2353922 | lld:pubmed |
