| pubmed-article:2342071 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C0021242 | lld:lifeskim |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C0021187 | lld:lifeskim |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:2342071 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:2342071 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2342071 | pubmed:dateCreated | 1990-6-28 | lld:pubmed |
| pubmed-article:2342071 | pubmed:abstractText | A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antagonists of peptidoleukotrienes. A systematic exploration of C-6 substituted 4-(indol-1-ylmethyl)-3-methoxybenzoic acids identified cyclopentylacetamide and cyclopentylurethane as preferred substituents. The corresponding indazoles were equipotent. These compounds are selective leukotriene antagonists with pKB values of 7.5-7.8 vs LTE4 on guinea pig trachea. | lld:pubmed |
| pubmed-article:2342071 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2342071 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342071 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2342071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342071 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2342071 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2342071 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:2342071 | pubmed:author | pubmed-author:KrellR DRD | lld:pubmed |
| pubmed-article:2342071 | pubmed:author | pubmed-author:SnyderD WDW | lld:pubmed |
| pubmed-article:2342071 | pubmed:author | pubmed-author:BrownF JFJ | lld:pubmed |
| pubmed-article:2342071 | pubmed:author | pubmed-author:CronkL ALA | lld:pubmed |
| pubmed-article:2342071 | pubmed:author | pubmed-author:FRYJ FJF | lld:pubmed |
| pubmed-article:2342071 | pubmed:author | pubmed-author:HebbelK CKC | lld:pubmed |
| pubmed-article:2342071 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2342071 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:2342071 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2342071 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2342071 | pubmed:pagination | 1771-81 | lld:pubmed |
| pubmed-article:2342071 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:meshHeading | pubmed-meshheading:2342071-... | lld:pubmed |
| pubmed-article:2342071 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2342071 | pubmed:articleTitle | Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles. | lld:pubmed |
| pubmed-article:2342071 | pubmed:affiliation | Department of Medicinal Chemistry, ICI Pharmaceuticals Group, Wilmington, Delaware 19897. | lld:pubmed |
| pubmed-article:2342071 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2342071 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:2342071 | lld:chembl |
