| pubmed-article:2341054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0031308 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0068355 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0162772 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0044496 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2341054 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:2341054 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2341054 | pubmed:dateCreated | 1990-6-28 | lld:pubmed |
| pubmed-article:2341054 | pubmed:abstractText | Activation of human neutrophils with opsonized particles in the presence of a nontoxic dose of 1-naphthol resulted in inhibition of superoxide anion production but not of the phagocytotic activity of the cells. In this study we have investigated the mechanism of action of 1-naphthol. The inhibition is not at the level of cellular activation since the FMLP-induced rise of intracellular free calcium was unaffected. Our results show that the (metabolic) activation of 1-naphthol to 1,4-naphthoquinone by reaction with H2O2 from the oxidative burst is a necessary event for the inhibition to occur. The study provides evidence that by its reactivity with essential thiol groups 1,4-naphthoquinone (1,4-NQ) prevents the assembly of a functional NADPH-oxidase in the neutrophil membrane. | lld:pubmed |
| pubmed-article:2341054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2341054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2341054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2341054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2341054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2341054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2341054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2341054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2341054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2341054 | pubmed:issn | 0891-5849 | lld:pubmed |
| pubmed-article:2341054 | pubmed:author | pubmed-author:HartB ABA | lld:pubmed |
| pubmed-article:2341054 | pubmed:author | pubmed-author:Van DijkHH | lld:pubmed |
| pubmed-article:2341054 | pubmed:author | pubmed-author:LabadieR PRP | lld:pubmed |
| pubmed-article:2341054 | pubmed:author | pubmed-author:SimonsJ MJM | lld:pubmed |
| pubmed-article:2341054 | pubmed:author | pubmed-author:RijkersG TGT | lld:pubmed |
| pubmed-article:2341054 | pubmed:author | pubmed-author:HoogvlietJ... | lld:pubmed |
| pubmed-article:2341054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2341054 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:2341054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2341054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2341054 | pubmed:pagination | 241-9 | lld:pubmed |
| pubmed-article:2341054 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:meshHeading | pubmed-meshheading:2341054-... | lld:pubmed |
| pubmed-article:2341054 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2341054 | pubmed:articleTitle | Reaction products of 1-naphthol with reactive oxygen species prevent NADPH oxidase activation in activated human neutrophils, but leave phagocytosis intact. | lld:pubmed |
| pubmed-article:2341054 | pubmed:affiliation | Department of Pharmacognosy, University of Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:2341054 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2341054 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2341054 | lld:pubmed |
