| pubmed-article:2306808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C0007770 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C0001041 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C0040057 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2306808 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:2306808 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2306808 | pubmed:dateCreated | 1990-4-6 | lld:pubmed |
| pubmed-article:2306808 | pubmed:abstractText | Previous studies have shown that cholinergic stimulation results in a prostanoid-dependent cerebral vasoconstriction in piglets. The present study specifically investigated the contribution of thromboxane A2 (TXA2)/prostaglandin endoperoxide and prostaglandin F2 alpha (PGF2 alpha) to the cerebral vascular response to exogenous acetylcholine (ACh). Effects of TXA2/prostaglandin endoperoxide-receptor antagonist SQ29548 on responsiveness of pial arterioles to ACh (10(-7) and 10(-4) M), PGF2 alpha (10(-7)-10(-5) M), TXA2 mimetic 9,11-methanoepoxy prostaglandin H2 (U46619, 5 and 10 ng/ml), and norepinephrine (10(-6)-10(-4) M) were studied by use of a closed cranial window in 37 anesthetized mechanically ventilated newborn piglets. Pial arteriolar diameter was measured by intravital microscopy. Topical application of exogenous PGF2 alpha and U46619 resulted in dose-dependent cerebral vasoconstriction, and the dose-response curve for each agonist was shifted to the right by the increasing concentrations of SQ29548 (10(-6)-10(-8) M). Topical application of high concentration of ACh (10(-4) M) caused a transient 34 +/- 4% decrease in pial arteriolar diameter from 98 +/- 6 to 65 +/- 5 microns (p less than 0.05). This constriction was attenuated (16 +/- 3%) in the presence of 10(-8) M SQ29548 and abolished with 10(-6) or 10(-4) M SQ29548. SQ29548 (10(-6) M) was without effect on the vasoconstrictor response to exogenous norepinephrine. Low concentration of ACh (10(-7) M) had no consistent effect on pial arterioles in the absence or presence of TXA2/prostaglandin endoperoxide-receptor blockade. The data suggest that vascular prostaglandin/endoperoxide receptors mediate cerebral vasoconstriction upon muscarinic-receptor stimulation. | lld:pubmed |
| pubmed-article:2306808 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2306808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2306808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2306808 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2306808 | pubmed:issn | 0009-7330 | lld:pubmed |
| pubmed-article:2306808 | pubmed:author | pubmed-author:BusijaD WDW | lld:pubmed |
| pubmed-article:2306808 | pubmed:author | pubmed-author:WagerleL CLC | lld:pubmed |
| pubmed-article:2306808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2306808 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:2306808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2306808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2306808 | pubmed:pagination | 824-31 | lld:pubmed |
| pubmed-article:2306808 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2306808 | pubmed:meshHeading | pubmed-meshheading:2306808-... | lld:pubmed |
| pubmed-article:2306808 | pubmed:meshHeading | pubmed-meshheading:2306808-... | lld:pubmed |
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| pubmed-article:2306808 | pubmed:meshHeading | pubmed-meshheading:2306808-... | lld:pubmed |
| pubmed-article:2306808 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2306808 | pubmed:articleTitle | Effect of thromboxane A2/endoperoxide antagonist SQ29548 on the contractile response to acetylcholine in newborn piglet cerebral arteries. | lld:pubmed |
| pubmed-article:2306808 | pubmed:affiliation | Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104. | lld:pubmed |
| pubmed-article:2306808 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2306808 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2306808 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2306808 | lld:pubmed |
