pubmed-article:2268281 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2268281 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:2268281 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
pubmed-article:2268281 | lifeskim:mentions | umls-concept:C0036581 | lld:lifeskim |
pubmed-article:2268281 | lifeskim:mentions | umls-concept:C0021994 | lld:lifeskim |
pubmed-article:2268281 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:2268281 | pubmed:dateCreated | 1991-2-14 | lld:pubmed |
pubmed-article:2268281 | pubmed:abstractText | Selenium (Se) deficiency decreased by 8-fold the activity of type 1 iodothyronine 5'-deiodinase (ID-I) in hepatic microsomal fractions from rats. Solubilized hepatic microsomes from rats injected with 75Se-labelled Na2SeO3 4 days before killing were found by chromatography on agarose gels to contain a 75Se-containing fraction with ID-I activity. PAGE of this fraction under reducing conditions, followed by autoradiography, revealed a single 75Se-containing protein (Mr 27,400 +/- 300). This protein could also be labelled with 125I-bromoacetyl reverse tri-iodothyronine, an affinity label for ID-I. The results suggest that hepatic ID-I is a selenoprotein or has an Se-containing subunit essential for activity. | lld:pubmed |
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pubmed-article:2268281 | pubmed:language | eng | lld:pubmed |
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pubmed-article:2268281 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:2268281 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2268281 | pubmed:month | Dec | lld:pubmed |
pubmed-article:2268281 | pubmed:issn | 0264-6021 | lld:pubmed |
pubmed-article:2268281 | pubmed:author | pubmed-author:BeckettG JGJ | lld:pubmed |
pubmed-article:2268281 | pubmed:author | pubmed-author:NicotNN | lld:pubmed |
pubmed-article:2268281 | pubmed:author | pubmed-author:ArthurJ RJR | lld:pubmed |
pubmed-article:2268281 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2268281 | pubmed:day | 1 | lld:pubmed |
pubmed-article:2268281 | pubmed:volume | 272 | lld:pubmed |
pubmed-article:2268281 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2268281 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2268281 | pubmed:pagination | 537-40 | lld:pubmed |
pubmed-article:2268281 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:2268281 | pubmed:year | 1990 | lld:pubmed |
pubmed-article:2268281 | pubmed:articleTitle | Hepatic iodothyronine 5'-deiodinase. The role of selenium. | lld:pubmed |
pubmed-article:2268281 | pubmed:affiliation | Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen, U.K. | lld:pubmed |
pubmed-article:2268281 | pubmed:publicationType | Journal Article | lld:pubmed |
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