| pubmed-article:2246164 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2246164 | lifeskim:mentions | umls-concept:C0034085 | lld:lifeskim |
| pubmed-article:2246164 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:2246164 | lifeskim:mentions | umls-concept:C0015684 | lld:lifeskim |
| pubmed-article:2246164 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:2246164 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:2246164 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2246164 | pubmed:dateCreated | 1991-1-8 | lld:pubmed |
| pubmed-article:2246164 | pubmed:abstractText | To determine whether acute fatty acid lung injury impairs pulmonary surfactant function, we studied anesthetized ventilated rabbits given oleic acid (55 mg/kg iv, n = 11) or an equivalent volume of saline (n = 8). Measurements of pulmonary mechanics indicated a decrease in dynamic compliance within 5 min of injury and a decrease in lung volume that was disproportionately large at low pressures, consistent with diminished surfactant activity in vivo. Bronchoalveolar lavage fluid obtained 1 h after injury had significantly increased erythrocytes and total leukocytes, largely polymorphonuclear cells. The phospholipid content and composition of the cell-free fraction had only minor changes from those of controls, but the protein content was increased 35-fold. Measurements of lavage surface activity in vitro showed an increase in average minimum surface tension from 1.3 +/- 0.4 (SE) dyn/cm in controls to 20.2 +/- 3.9 dyn/cm in injured animals. The alterations in static pressure-volume curves and decrease in lavage surface activity suggest a severe alteration of surfactant function in this form of lung injury that occurs despite the presence of normal amounts of surfactant phospholipids. | lld:pubmed |
| pubmed-article:2246164 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2246164 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2246164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246164 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2246164 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2246164 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:2246164 | pubmed:author | pubmed-author:SmithR JRJ | lld:pubmed |
| pubmed-article:2246164 | pubmed:author | pubmed-author:HydeR WRW | lld:pubmed |
| pubmed-article:2246164 | pubmed:author | pubmed-author:NotterR HRH | lld:pubmed |
| pubmed-article:2246164 | pubmed:author | pubmed-author:HallS BSB | lld:pubmed |
| pubmed-article:2246164 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2246164 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:2246164 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2246164 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2246164 | pubmed:pagination | 1143-9 | lld:pubmed |
| pubmed-article:2246164 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2246164 | pubmed:meshHeading | pubmed-meshheading:2246164-... | lld:pubmed |
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| pubmed-article:2246164 | pubmed:meshHeading | pubmed-meshheading:2246164-... | lld:pubmed |
| pubmed-article:2246164 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2246164 | pubmed:articleTitle | Altered function of pulmonary surfactant in fatty acid lung injury. | lld:pubmed |
| pubmed-article:2246164 | pubmed:affiliation | Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642. | lld:pubmed |
| pubmed-article:2246164 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2246164 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2246164 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2246164 | lld:pubmed |
