| pubmed-article:2226626 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0020649 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C1157570 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2226626 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2226626 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2226626 | pubmed:dateCreated | 1990-12-12 | lld:pubmed |
| pubmed-article:2226626 | pubmed:abstractText | E. coli lipopolysaccharide (LPS; 15 mg kg-1 i.v.) produced a long-lasting reduction in mean arterial blood pressure (MAP) in the anaesthetized rat. Inhibition of nitric oxide endothelium-derived relaxing factor (EDRF) synthesis with NG-monomethyl-L-arginine (MeArg, 1 mg kg-1 min-1 i.v. for 30 min) produced an increase in MAP and largely attenuated the LPS-induced hypotension; both effects were significantly reversed with L-arginine (6 mg kg-1 min-1 i.v.). When compared to MeArg, phenylephrine (300 mg kg-1 h-1 i.v.) produced a similar pressor response, but much less attenuation of the hypotensive response to LPS. Thus, a stimulation of EDRF release contributes to the LPS-induced hypotension in the anaesthetized rat. | lld:pubmed |
| pubmed-article:2226626 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2226626 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2226626 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2226626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2226626 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2226626 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2226626 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:2226626 | pubmed:author | pubmed-author:VaneJJ | lld:pubmed |
| pubmed-article:2226626 | pubmed:author | pubmed-author:ThiemermannCC | lld:pubmed |
| pubmed-article:2226626 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2226626 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:2226626 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:2226626 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2226626 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2226626 | pubmed:pagination | 591-5 | lld:pubmed |
| pubmed-article:2226626 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2226626 | pubmed:meshHeading | pubmed-meshheading:2226626-... | lld:pubmed |
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| pubmed-article:2226626 | pubmed:meshHeading | pubmed-meshheading:2226626-... | lld:pubmed |
| pubmed-article:2226626 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2226626 | pubmed:articleTitle | Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. | lld:pubmed |
| pubmed-article:2226626 | pubmed:affiliation | William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, U.K. | lld:pubmed |
| pubmed-article:2226626 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2226626 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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