| pubmed-article:2209692 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C0175668 | lld:lifeskim |
| pubmed-article:2209692 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:2209692 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2209692 | pubmed:dateCreated | 1990-11-2 | lld:pubmed |
| pubmed-article:2209692 | pubmed:abstractText | BALB/c mice immunized with keyhole limpet hemocyanin (KLH) develop Thy-1+ and CD8+, KLH-specific cytotoxic T cells (Tc). Such Tc cells can lyse TNP-specific B cells activated with TNP-KLH, but not with TNP-ovalbumin. Cytotoxicity was inhibited by anti-H-2K/D antibodies, but not by anti-Ia antibodies, suggesting a major histocompatibility complex class I-restricted killing. Selective enrichment for virgin and memory TNP-specific B cells revealed that the latter cells were relatively resistant to lysis by KLH-specific Tc cells. Depletion of CD8+ T cells from cultures of TNP-specific virgin B cells activated with TNP-KLH and KLH-primed T cells, increased the titer of anti-TNP antibodies in the culture supernatants. This increase was reduced if KLH-primed CD8+ T cells were added to the culture 1 day before its termination. Anti-TNP antibody secretion by memory B cells activated in the same manner was not affected by depletion or addition of CD8+ cells. These results suggest that Tc cells are generated following immunization with a soluble antigen which may participate in the down-regulation of primary B cell responses. | lld:pubmed |
| pubmed-article:2209692 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2209692 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2209692 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2209692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2209692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2209692 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2209692 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2209692 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:2209692 | pubmed:author | pubmed-author:YefenofEE | lld:pubmed |
| pubmed-article:2209692 | pubmed:author | pubmed-author:GuyRR | lld:pubmed |
| pubmed-article:2209692 | pubmed:author | pubmed-author:Zehavi-Feferm... | lld:pubmed |
| pubmed-article:2209692 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2209692 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:2209692 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2209692 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2209692 | pubmed:pagination | 1849-53 | lld:pubmed |
| pubmed-article:2209692 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:meshHeading | pubmed-meshheading:2209692-... | lld:pubmed |
| pubmed-article:2209692 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2209692 | pubmed:articleTitle | Control of primary and secondary antibody responses by cytotoxic T lymphocytes specific for a soluble antigen. | lld:pubmed |
| pubmed-article:2209692 | pubmed:affiliation | Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:2209692 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2209692 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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