| pubmed-article:21791429 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21791429 | lifeskim:mentions | umls-concept:C0812314 | lld:lifeskim |
| pubmed-article:21791429 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:21791429 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:21791429 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:21791429 | pubmed:dateCreated | 2011-9-9 | lld:pubmed |
| pubmed-article:21791429 | pubmed:abstractText | Interferon regulatory factor 4 (IRF4) is a member of the interferon regulatory factor family of transcription factors and has been shown to have critical functions at several stages of B-cell development. Genome-wide association study identified a polymorphism in the 3' untranslated region of IRF4 as a chronic lymphocytic leukemia risk locus. In this study, we report a recurrent heterozygous somatic mutation in the DNA-binding domain of IRF4 detected in 7 of 457 chronic lymphocytic leukemia patients (1.5%). Patients with IRF4 mutation have a good prognosis, and 4 of 6 have a trisomy 12. We also found that IRF4 mRNA expression is higher in the patients with the mutation. | lld:pubmed |
| pubmed-article:21791429 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21791429 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21791429 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21791429 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21791429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21791429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21791429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21791429 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21791429 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:21791429 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:CroceCarlo... | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:AlderHansjuer... | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:NakamuraTatsu... | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:RassentiLaura... | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:PekarskyYuriY | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:PalamarchukAl... | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:KippsThomasT | lld:pubmed |
| pubmed-article:21791429 | pubmed:author | pubmed-author:HavelangeViol... | lld:pubmed |
| pubmed-article:21791429 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21791429 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:21791429 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:21791429 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21791429 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21791429 | pubmed:pagination | 2827-9 | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:meshHeading | pubmed-meshheading:21791429... | lld:pubmed |
| pubmed-article:21791429 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21791429 | pubmed:articleTitle | IRF4 mutations in chronic lymphocytic leukemia. | lld:pubmed |
| pubmed-article:21791429 | pubmed:affiliation | Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. | lld:pubmed |
| pubmed-article:21791429 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21791429 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21791429 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:3662 | entrezgene:pubmed | pubmed-article:21791429 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21791429 | lld:entrezgene |
