| pubmed-article:21685874 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C1167139 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C2613317 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:21685874 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:21685874 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:21685874 | pubmed:dateCreated | 2011-7-20 | lld:pubmed |
| pubmed-article:21685874 | pubmed:abstractText | The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex is an important chromatin modifying complex that can both acetylate and deubiquitinate histones. Sgf29 is a novel component of the SAGA complex. Here, we report the crystal structures of the tandem Tudor domains of Saccharomyces cerevisiae and human Sgf29 and their complexes with H3K4me2 and H3K4me3 peptides, respectively, and show that Sgf29 selectively binds H3K4me2/3 marks. Our crystal structures reveal that Sgf29 harbours unique tandem Tudor domains in its C-terminus. The tandem Tudor domains in Sgf29 tightly pack against each other face-to-face with each Tudor domain harbouring a negatively charged pocket accommodating the first residue alanine and methylated K4 residue of histone H3, respectively. The H3A1 and K4me3 binding pockets and the limited binding cleft length between these two binding pockets are the structural determinants in conferring the ability of Sgf29 to selectively recognize H3K4me2/3. Our in vitro and in vivo functional assays show that Sgf29 recognizes methylated H3K4 to recruit the SAGA complex to its targets sites and mediates histone H3 acetylation, underscoring the importance of Sgf29 in gene regulation. | lld:pubmed |
| pubmed-article:21685874 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21685874 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685874 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21685874 | pubmed:issn | 1460-2075 | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:TempelWolfram... | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:LiJingJ | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:GrantPatrick... | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:WorkmanJerry... | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:LeeKenneth... | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:ZhouJin-QiuJQ | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:Allali-Hassan... | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:MinJinrongJ | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:EideA JAJ | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:ZangJianyeJ | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:MerGeorgesG | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:BurkeTara LTL | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:BianChuanbing... | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:WuMinhaoM | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:PaulsonArielA | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:ZhouBo OBO | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:RuanJianbinJ | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:BarsyteDaliaD | lld:pubmed |
| pubmed-article:21685874 | pubmed:author | pubmed-author:FlehartyBrian... | lld:pubmed |
| pubmed-article:21685874 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21685874 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:21685874 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21685874 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21685874 | pubmed:pagination | 2829-42 | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:meshHeading | pubmed-meshheading:21685874... | lld:pubmed |
| pubmed-article:21685874 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21685874 | pubmed:articleTitle | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. | lld:pubmed |
| pubmed-article:21685874 | pubmed:affiliation | School of Life Sciences, University of Science and Technology of China, Anhui, People's Republic of China. | lld:pubmed |
| pubmed-article:21685874 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21685874 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21685874 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21685874 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:112869 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:852059 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:853167 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:851756 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:856499 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:852766 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:852295 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:855700 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:851723 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:1466445 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:855821 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:850347 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:850744 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:852373 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:856060 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:852814 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:854017 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:852001 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:851745 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:855276 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| entrez-gene:855263 | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21685874 | lld:entrezgene |
