| pubmed-article:21683687 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C0004015 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1819586 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:21683687 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:21683687 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21683687 | pubmed:dateCreated | 2011-7-18 | lld:pubmed |
| pubmed-article:21683687 | pubmed:abstractText | The high affinity IgE Fc receptor (Fc?RI) ? chain is well implicated as a signal amplifier through the immunoreceptor tyrosine-based activation motif (ITAM) in its C-terminal intracellular region. Our previous study, however, demonstrated that mutation in all of the three tyrosine residues within the Fc?RI? ITAM did not impair Fc?RI-induced cytokine production, suggesting a possible functional region other than the ITAM. To investigate the ITAM-independent mechanism by which Fc?RI? regulates Fc?RI-induced cytokine production, mouse mast cells expressing various Fc?RI? mutants were generated. We observed that truncation of the Fc?RI? C-terminus downstream of the ITAM resulted in a considerable decrease in Fc?RI-induced IL-6 production but not degranulation. Furthermore, mutagenesis of a single C-terminal aspartic acid (D234) to alanine (?-D234A) also significantly impaired IL-6 production. In addition, the similarity between the circular dichroism (CD) spectra of the wild type and ?-D234A suggests that the secondary structure of the Fc?RI? C-terminus was not affected by the D234A mutation. Consistently, we did not observe any effect of this mutation on Fc?RI-induced tyrosine phosphorylation of Fc?RI?. These observations strongly suggest a novel signaling pathway mediated by the cytoplasmic tail downstream of the Fc?RI? ITAM. | lld:pubmed |
| pubmed-article:21683687 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21683687 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21683687 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21683687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21683687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21683687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21683687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21683687 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21683687 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21683687 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:21683687 | pubmed:author | pubmed-author:EraSeiichiS | lld:pubmed |
| pubmed-article:21683687 | pubmed:author | pubmed-author:RaChiseiC | lld:pubmed |
| pubmed-article:21683687 | pubmed:author | pubmed-author:KondoNaomiN | lld:pubmed |
| pubmed-article:21683687 | pubmed:author | pubmed-author:MurayamaKoich... | lld:pubmed |
| pubmed-article:21683687 | pubmed:author | pubmed-author:ShimokawaTosh... | lld:pubmed |
| pubmed-article:21683687 | pubmed:author | pubmed-author:NunomuraSatos... | lld:pubmed |
| pubmed-article:21683687 | pubmed:author | pubmed-author:TeradaTomoyos... | lld:pubmed |
| pubmed-article:21683687 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21683687 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21683687 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21683687 | pubmed:volume | 410 | lld:pubmed |
| pubmed-article:21683687 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21683687 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21683687 | pubmed:pagination | 744-8 | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:meshHeading | pubmed-meshheading:21683687... | lld:pubmed |
| pubmed-article:21683687 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21683687 | pubmed:articleTitle | Fc?RI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the Fc?RI? chain. | lld:pubmed |
| pubmed-article:21683687 | pubmed:affiliation | Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Tokyo, Japan. | lld:pubmed |
| pubmed-article:21683687 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21683687 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14126 | entrezgene:pubmed | pubmed-article:21683687 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21683687 | lld:entrezgene |
